Combination Antibiotic Therapy Lowers Mortality among Severely III Patients with Pneumococcal Bacteremia

Larry M. Baddour; Victor L. Yu; Keith P. Klugman; Charles Feldman; Ake Ortqvist; Jordi Rello; Arthur J. Morris; Carlos M. Luna; David R. Snydman; Chien Ko Wen; M. Bernadete F. Chedid; David S. Hui; Antoine Andremont; Christine C.C. Chiou; Ricardo Mosquera; Carmen De Mier; Angela Famiglietti; Carlos Vay; Jorge Gentile; Monica Sparo; Sergio Menna Barreto; Afonso L. Barth; Cicero Dias; Breno Riegel Dos Santos; Karine Grenet; Hyam Mounieme; Margaret Ip; Donald Lyon; Sally A. Roberts; Dragana Drinkovic; Susan L. Taylor; Anne Von Gottberg; Xoliswa Poswa; Rajen Morar; Miquel Gallego; M. Lujan; Emili Diaz; Dolors Mariscal; Dionisia Fontanals; Jose M. Santamaria; Margareta Rylander; Feng Yee Chang; Wen Pin Wu; Chia Yi; Laurie Barefoot; Laura McDermott; David L. Blazes; Gregory Marin; Mandana Mobasseri; Dong Hoon Daniel Kim; John D. Rihs

doi:10.1164/rccm.200311-1578OC

Combination Antibiotic Therapy Lowers Mortality among Severely III Patients with Pneumococcal Bacteremia

Larry M. Baddour
, Victor L. Yu
, Keith P. Klugman
, Charles Feldman
, Ake Ortqvist
, Jordi Rello
, Arthur J. Morris
, Carlos M. Luna
, David R. Snydman
, Chien Ko Wen
, M. Bernadete F. Chedid
, David S. Hui
, Antoine Andremont
, Christine C.C. Chiou
, Ricardo Mosquera
, Carmen De Mier
, Angela Famiglietti
, Carlos Vay
, Jorge Gentile
, Monica Sparo

Sergio Menna Barreto, Afonso L. Barth, Cicero Dias, Breno Riegel Dos Santos, Karine Grenet, Hyam Mounieme, Margaret Ip, Donald Lyon, Sally A. Roberts, Dragana Drinkovic, Susan L. Taylor, Anne Von Gottberg, Xoliswa Poswa, Rajen Morar, Miquel Gallego, M. Lujan, Emili Diaz, Dolors Mariscal, Dionisia Fontanals, Jose M. Santamaria, Margareta Rylander, Feng Yee Chang, Wen Pin Wu, Chia Yi, Laurie Barefoot, Laura McDermott, David L. Blazes, Gregory Marin, Mandana Mobasseri, Dong Hoon Daniel Kim, John D. Rihs

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

385 Citations (Scopus)

Abstract

Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combination antibiotic therapy versus monotherapy on mortality was examined by univariate analyses and by logistic regression models. The 14-day mortality was not significantly different for the two groups. However, among critically ill patients, combination antibiotic therapy was associated with lower 14-day mortality (23.4 versus 55.3%, p = 0.0015). This improvement in survival was independent of country of origin, intensive care unit support, class of antibiotics, or in vitro activity of the antibiotics prescribed. Combination antibiotic therapy improved survival among critically ill patients with bacteremic pneumococcal illness.

Original language	English
Pages (from-to)	440-444
Number of pages	5
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	170
Issue number	4
DOIs	https://doi.org/10.1164/rccm.200311-1578OC
Publication status	Published - 2004 Aug 15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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10.1164/rccm.200311-1578OC

Cite this

Baddour, L. M., Yu, V. L., Klugman, K. P., Feldman, C., Ortqvist, A., Rello, J., Morris, A. J., Luna, C. M., Snydman, D. R., Wen, C. K., Chedid, M. B. F., Hui, D. S., Andremont, A., Chiou, C. C. C., Mosquera, R., De Mier, C., Famiglietti, A., Vay, C., Gentile, J., ... Rihs, J. D. (2004). Combination Antibiotic Therapy Lowers Mortality among Severely III Patients with Pneumococcal Bacteremia. American Journal of Respiratory and Critical Care Medicine, 170(4), 440-444. https://doi.org/10.1164/rccm.200311-1578OC

@article{f40c0c6bf2dc4e79acc6d9d90d57c20b,

title = "Combination Antibiotic Therapy Lowers Mortality among Severely III Patients with Pneumococcal Bacteremia",

abstract = "Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combination antibiotic therapy versus monotherapy on mortality was examined by univariate analyses and by logistic regression models. The 14-day mortality was not significantly different for the two groups. However, among critically ill patients, combination antibiotic therapy was associated with lower 14-day mortality (23.4 versus 55.3\%, p = 0.0015). This improvement in survival was independent of country of origin, intensive care unit support, class of antibiotics, or in vitro activity of the antibiotics prescribed. Combination antibiotic therapy improved survival among critically ill patients with bacteremic pneumococcal illness.",

author = "Baddour, \{Larry M.\} and Yu, \{Victor L.\} and Klugman, \{Keith P.\} and Charles Feldman and Ake Ortqvist and Jordi Rello and Morris, \{Arthur J.\} and Luna, \{Carlos M.\} and Snydman, \{David R.\} and Wen, \{Chien Ko\} and Chedid, \{M. Bernadete F.\} and Hui, \{David S.\} and Antoine Andremont and Chiou, \{Christine C.C.\} and Ricardo Mosquera and \{De Mier\}, Carmen and Angela Famiglietti and Carlos Vay and Jorge Gentile and Monica Sparo and Barreto, \{Sergio Menna\} and Barth, \{Afonso L.\} and Cicero Dias and \{Dos Santos\}, \{Breno Riegel\} and Karine Grenet and Hyam Mounieme and Margaret Ip and Donald Lyon and Roberts, \{Sally A.\} and Dragana Drinkovic and Taylor, \{Susan L.\} and \{Von Gottberg\}, Anne and Xoliswa Poswa and Rajen Morar and Miquel Gallego and M. Lujan and Emili Diaz and Dolors Mariscal and Dionisia Fontanals and Santamaria, \{Jose M.\} and Margareta Rylander and Chang, \{Feng Yee\} and Wu, \{Wen Pin\} and Chia Yi and Laurie Barefoot and Laura McDermott and Blazes, \{David L.\} and Gregory Marin and Mandana Mobasseri and Kim, \{Dong Hoon Daniel\} and Rihs, \{John D.\}",

year = "2004",

month = aug,

day = "15",

doi = "10.1164/rccm.200311-1578OC",

language = "English",

volume = "170",

pages = "440--444",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "Oxford University Press",

number = "4",

}

Baddour, LM, Yu, VL, Klugman, KP, Feldman, C, Ortqvist, A, Rello, J, Morris, AJ, Luna, CM, Snydman, DR, Wen, CK, Chedid, MBF, Hui, DS, Andremont, A, Chiou, CCC, Mosquera, R, De Mier, C, Famiglietti, A, Vay, C, Gentile, J, Sparo, M, Barreto, SM, Barth, AL, Dias, C, Dos Santos, BR, Grenet, K, Mounieme, H, Ip, M, Lyon, D, Roberts, SA, Drinkovic, D, Taylor, SL, Von Gottberg, A, Poswa, X, Morar, R, Gallego, M, Lujan, M, Diaz, E, Mariscal, D, Fontanals, D, Santamaria, JM, Rylander, M, Chang, FY, Wu, WP, Yi, C, Barefoot, L, McDermott, L, Blazes, DL, Marin, G, Mobasseri, M, Kim, DHD & Rihs, JD 2004, 'Combination Antibiotic Therapy Lowers Mortality among Severely III Patients with Pneumococcal Bacteremia', American Journal of Respiratory and Critical Care Medicine, vol. 170, no. 4, pp. 440-444. https://doi.org/10.1164/rccm.200311-1578OC

TY - JOUR

T1 - Combination Antibiotic Therapy Lowers Mortality among Severely III Patients with Pneumococcal Bacteremia

AU - Baddour, Larry M.

AU - Yu, Victor L.

AU - Klugman, Keith P.

AU - Feldman, Charles

AU - Ortqvist, Ake

AU - Rello, Jordi

AU - Morris, Arthur J.

AU - Luna, Carlos M.

AU - Snydman, David R.

AU - Wen, Chien Ko

AU - Chedid, M. Bernadete F.

AU - Hui, David S.

AU - Andremont, Antoine

AU - Chiou, Christine C.C.

AU - Mosquera, Ricardo

AU - De Mier, Carmen

AU - Famiglietti, Angela

AU - Vay, Carlos

AU - Gentile, Jorge

AU - Sparo, Monica

AU - Barreto, Sergio Menna

AU - Barth, Afonso L.

AU - Dias, Cicero

AU - Dos Santos, Breno Riegel

AU - Grenet, Karine

AU - Mounieme, Hyam

AU - Ip, Margaret

AU - Lyon, Donald

AU - Roberts, Sally A.

AU - Drinkovic, Dragana

AU - Taylor, Susan L.

AU - Von Gottberg, Anne

AU - Poswa, Xoliswa

AU - Morar, Rajen

AU - Gallego, Miquel

AU - Lujan, M.

AU - Diaz, Emili

AU - Mariscal, Dolors

AU - Fontanals, Dionisia

AU - Santamaria, Jose M.

AU - Rylander, Margareta

AU - Chang, Feng Yee

AU - Wu, Wen Pin

AU - Yi, Chia

AU - Barefoot, Laurie

AU - McDermott, Laura

AU - Blazes, David L.

AU - Marin, Gregory

AU - Mobasseri, Mandana

AU - Kim, Dong Hoon Daniel

AU - Rihs, John D.

PY - 2004/8/15

Y1 - 2004/8/15

N2 - Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combination antibiotic therapy versus monotherapy on mortality was examined by univariate analyses and by logistic regression models. The 14-day mortality was not significantly different for the two groups. However, among critically ill patients, combination antibiotic therapy was associated with lower 14-day mortality (23.4 versus 55.3%, p = 0.0015). This improvement in survival was independent of country of origin, intensive care unit support, class of antibiotics, or in vitro activity of the antibiotics prescribed. Combination antibiotic therapy improved survival among critically ill patients with bacteremic pneumococcal illness.

AB - Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combination antibiotic therapy versus monotherapy on mortality was examined by univariate analyses and by logistic regression models. The 14-day mortality was not significantly different for the two groups. However, among critically ill patients, combination antibiotic therapy was associated with lower 14-day mortality (23.4 versus 55.3%, p = 0.0015). This improvement in survival was independent of country of origin, intensive care unit support, class of antibiotics, or in vitro activity of the antibiotics prescribed. Combination antibiotic therapy improved survival among critically ill patients with bacteremic pneumococcal illness.

UR - https://www.scopus.com/pages/publications/4544244010

UR - https://www.scopus.com/pages/publications/4544244010#tab=citedBy

U2 - 10.1164/rccm.200311-1578OC

DO - 10.1164/rccm.200311-1578OC

M3 - Article

C2 - 15184200

AN - SCOPUS:4544244010

SN - 1073-449X

VL - 170

SP - 440

EP - 444

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 4

ER -

Combination Antibiotic Therapy Lowers Mortality among Severely III Patients with Pneumococcal Bacteremia

Abstract

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