Combination of risperidone and fluoxetine in the treatment of schizophrenia-like disorder in a patient with frontal lobe meningioma and oral cancer

We report a case of a patient with schizophrenia-like disorder related to the right-side frontal lobe meningioma and oral cancer. This 55-year-old female began to show symptoms of talking to herself, insomnia, psychomotor agitation, persecutory delusions, violent behavior, and auditory and visual hallucinations, after the surgery for her oral cancer. The brain imaging studies revealed one right frontal lobe meningioma. The combination of risperidone and fluoxetine has successfully resolved the schizophrenia-like psychotic disorder related to both frontal lobe meningioma and mood disorder related to the body disfigurement due to the oral cancer surgery. This report aims to serve as a reminder for clinicians who are responsible for the treatment of the psychotic disorders in patients with concurrent brain and extracerebral tumors.