Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

P. H. Tan; L. C. Yang; H. C. Shih; C. R. Lin; K. C. Lan; C. S. Chen

doi:10.1046/j.1365-2044.2002.02624_4.x

Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

P. H. Tan, L. C. Yang, H. C. Shih, C. R. Lin, K. C. Lan, C. S. Chen

Department of Anesthesiology(NCKUH)

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg^-1) and nicardipine (15 or 30 μg.kg^-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg^-1 and nicardipine 30 μg.kg^-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

Original language	English
Pages (from-to)	1207-1212
Number of pages	6
Journal	Anaesthesia
Volume	57
Issue number	12
DOIs	https://doi.org/10.1046/j.1365-2044.2002.02624_4.x
Publication status	Published - 2002 Dec 1

All Science Journal Classification (ASJC) codes

Anesthesiology and Pain Medicine

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abstract = "We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg-1) and nicardipine (15 or 30 μg.kg-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg-1 and nicardipine 30 μg.kg-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).",

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AU - Tan, P. H.

AU - Yang, L. C.

AU - Shih, H. C.

AU - Lin, C. R.

AU - Lan, K. C.

AU - Chen, C. S.

PY - 2002/12/1

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Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

Abstract

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