Comparative pathogenicity of bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae

Wen-Chien Ko, S. R. Chiang, J. J. Yan, Y. C. Chuang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Two bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae, Ah-2743 and Kp-129, respectively, were studied for their relative pathogenicity in comparison with Escherichia coli ATCC 25922. Ah-2743 caused significantly higher serum levels of tumour necrosis factor-α, interleukin (IL)-1β or IL-6 in human whole blood, and higher serum IL-1β and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. In addition, in BALB/c mice infected by intraperitoneal inoculation, Ah-2743 caused a higher fatality rate (80%) than did Kp-129 (0%). With intramuscular inoculation, Ah-2743 caused more rapid and intense local accumulation of inflammatory cells than did Kp-129, and myonecrosis was present only in Ah-2743-infected mice. These data indicate that Ah-2743 is more pathogenic than Kp-129 or E. coli ATCC 25922 for BALB/c mice. The cellular components or extracellular factors associated with increased cytokine induction and pathogenicity of A. hydrophila in mice merit further investigation.

Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalClinical Microbiology and Infection
Volume11
Issue number7
DOIs
Publication statusPublished - 2005 Jan 1

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Aeromonas hydrophila
Klebsiella pneumoniae
Virulence
Escherichia coli
Interleukin-1
Interleukin-6
129 Strain Mouse
Serum
Tumor Necrosis Factor-alpha
Cytokines

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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abstract = "Two bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae, Ah-2743 and Kp-129, respectively, were studied for their relative pathogenicity in comparison with Escherichia coli ATCC 25922. Ah-2743 caused significantly higher serum levels of tumour necrosis factor-α, interleukin (IL)-1β or IL-6 in human whole blood, and higher serum IL-1β and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. In addition, in BALB/c mice infected by intraperitoneal inoculation, Ah-2743 caused a higher fatality rate (80{\%}) than did Kp-129 (0{\%}). With intramuscular inoculation, Ah-2743 caused more rapid and intense local accumulation of inflammatory cells than did Kp-129, and myonecrosis was present only in Ah-2743-infected mice. These data indicate that Ah-2743 is more pathogenic than Kp-129 or E. coli ATCC 25922 for BALB/c mice. The cellular components or extracellular factors associated with increased cytokine induction and pathogenicity of A. hydrophila in mice merit further investigation.",
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Comparative pathogenicity of bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae. / Ko, Wen-Chien; Chiang, S. R.; Yan, J. J.; Chuang, Y. C.

In: Clinical Microbiology and Infection, Vol. 11, No. 7, 01.01.2005, p. 553-558.

Research output: Contribution to journalArticle

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