Comparing the spatial and temporal reproducibility of brain activation using three fMRI techniques

BOLD, FAIR, and VASO

Chia Wei Lee, Der-Yow Chen, Chang Wei Wu, Jyh Horng Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In order to conduct the longitudinal fMRI study, measuring of the reproducibility of functional imaging is important. Our immediate study, we compared the spatial activation map reproducibility of three fMRI techniques with 8Hz checkerboard visual stimuli in three experiment sessions. The interval from experiment session one session two is one hour, and the interval form experiment session one to session three is three months. In addition to traditional blood oxygenation level dependent (BOLD) 11,121 fMRI, CBF and CBV fMRI measured by flow-sensitive alternating inversion recovery (FAIR) [3][4][5] and vascular space occupancy (VASO) [6] techniques were also used. The latter two developed techniques are more suitable in comparing the longitudinal variation of single subject or among subjects since the quantification capability of CBF and CBV. However, signal change of FAIR and VASO is smaller than BOLD (1/2 and 1/3, respectively) and may reduce the reproducibility of fMRI activation. An equivalent ROI of three techniques was selected in which contained all the activation areas located around primary visual cortex Percentage of activation overlapping was then calculated from three experiments. The mean overlapping percentage of 7 participants between experiment session one and two was 67.0%, 63.7%, and 65.2%, for BOLD, FAIR, and VASO respectively. There is no significant difference in reproducibility among these techniques. Although FAIR showed slightly better overlapping percentage (61.9%) than the percentage of BOLD and VASO (54.0% and 56.7%) in experiment session one and three, there is still no significant difference between three fMRI techniques. This result indicated that there is no significant difference of reproducibility between three fMRI techniques, although FAIR and VASO show smaller signal change than BOLD.

Original languageEnglish
Title of host publicationProc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007
Pages258-261
Number of pages4
DOIs
Publication statusPublished - 2007 Dec 1
Event2007 Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the International Conference on Functional Biomedical Imaging, NFSI and ICFBI 2007 - Hangzhou, China
Duration: 2007 Oct 122007 Oct 14

Publication series

NameProc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007

Other

Other2007 Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the International Conference on Functional Biomedical Imaging, NFSI and ICFBI 2007
CountryChina
CityHangzhou
Period07-10-1207-10-14

Fingerprint

Oxygenation
Blood Vessels
Brain
Blood
Chemical activation
Magnetic Resonance Imaging
Recovery
Experiments
Visual Cortex
Longitudinal Studies
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Lee, C. W., Chen, D-Y., Wu, C. W., & Chen, J. H. (2007). Comparing the spatial and temporal reproducibility of brain activation using three fMRI techniques: BOLD, FAIR, and VASO. In Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007 (pp. 258-261). [4387745] (Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007). https://doi.org/10.1109/NFSI-ICFBI.2007.4387745
Lee, Chia Wei ; Chen, Der-Yow ; Wu, Chang Wei ; Chen, Jyh Horng. / Comparing the spatial and temporal reproducibility of brain activation using three fMRI techniques : BOLD, FAIR, and VASO. Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007. 2007. pp. 258-261 (Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007).
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Lee, CW, Chen, D-Y, Wu, CW & Chen, JH 2007, Comparing the spatial and temporal reproducibility of brain activation using three fMRI techniques: BOLD, FAIR, and VASO. in Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007., 4387745, Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007, pp. 258-261, 2007 Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the International Conference on Functional Biomedical Imaging, NFSI and ICFBI 2007, Hangzhou, China, 07-10-12. https://doi.org/10.1109/NFSI-ICFBI.2007.4387745

Comparing the spatial and temporal reproducibility of brain activation using three fMRI techniques : BOLD, FAIR, and VASO. / Lee, Chia Wei; Chen, Der-Yow; Wu, Chang Wei; Chen, Jyh Horng.

Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007. 2007. p. 258-261 4387745 (Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lee CW, Chen D-Y, Wu CW, Chen JH. Comparing the spatial and temporal reproducibility of brain activation using three fMRI techniques: BOLD, FAIR, and VASO. In Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007. 2007. p. 258-261. 4387745. (Proc. of 2007 Joint Meet. of the 6th Int. Symp. on Noninvasive Functional Source Imaging of the Brain and Heart and the Int. Conf. on Functional Biomedical Imaging, NFSI and ICFBI 2007). https://doi.org/10.1109/NFSI-ICFBI.2007.4387745