TY - JOUR
T1 - Comparison of brain serotonin transporter using [I-123]-ADAM between obese and nonobese young adults without an eating disorder
AU - Wu, Chih Hsing
AU - Chang, Chin Sung
AU - Yang, Yen Kuang
AU - Shen, Lie Hang
AU - Yao, Wei Jen
N1 - Publisher Copyright:
© 2017 Wu et al.
PY - 2017/2
Y1 - 2017/2
N2 - Cerebral serotonin metabolism has an important but controversial role in obesity. However, it is not given enough attention in morbidly obese young adults. We used single photon emission computed tomography (SPECT) with [I-123]-labeled 2-((2-((dimethylamino) methyl)phenyl)thio)-5-iodophenylamine (ADAM) to investigate changes in serotonin transporter (SERT) availability in 10 morbidly obese young adults without an eating disorder (M/F = 5/5, body mass index (BMI): 40.3 ±4.1 kg/m2, percentage of body fat (BF%): 46.0 ± 3.9%) and 10 age-and sex-matched non-obese controls (BMI: 20.3 ± 1.2 kg/m2, BF%: 20.6 ± 8.9%). All participants underwent SPECT at 10 min and 6 h after an injection of 200 MBq of [I-123]-ADAM. The SERT binding site (midbrain) was drawn with cerebellum normalization. The BF% and fat distribution were measured using dual-energy X-ray absorptiometry. The midbrain/cerebellum SERT binding ratios (2.49 ± 0.46 vs. 2.47 ± 0.47; p = 0.912) at 6 h were not significantly different between groups, nor was the distribution of the summed images at 10 min (1.36 ±0.14 vs. 1.35 ±0.11; p = 0.853). There were no significant correlations between midbrain/cerebellum SERT binding ratio and age, BMI, BF%, or fat distribution. No significant difference in SERT availability in the midbrain between morbidly obese and nonobese young adults without an eating disorder indicates an unmet need for investigating the role of cerebral serotonin in obesity.
AB - Cerebral serotonin metabolism has an important but controversial role in obesity. However, it is not given enough attention in morbidly obese young adults. We used single photon emission computed tomography (SPECT) with [I-123]-labeled 2-((2-((dimethylamino) methyl)phenyl)thio)-5-iodophenylamine (ADAM) to investigate changes in serotonin transporter (SERT) availability in 10 morbidly obese young adults without an eating disorder (M/F = 5/5, body mass index (BMI): 40.3 ±4.1 kg/m2, percentage of body fat (BF%): 46.0 ± 3.9%) and 10 age-and sex-matched non-obese controls (BMI: 20.3 ± 1.2 kg/m2, BF%: 20.6 ± 8.9%). All participants underwent SPECT at 10 min and 6 h after an injection of 200 MBq of [I-123]-ADAM. The SERT binding site (midbrain) was drawn with cerebellum normalization. The BF% and fat distribution were measured using dual-energy X-ray absorptiometry. The midbrain/cerebellum SERT binding ratios (2.49 ± 0.46 vs. 2.47 ± 0.47; p = 0.912) at 6 h were not significantly different between groups, nor was the distribution of the summed images at 10 min (1.36 ±0.14 vs. 1.35 ±0.11; p = 0.853). There were no significant correlations between midbrain/cerebellum SERT binding ratio and age, BMI, BF%, or fat distribution. No significant difference in SERT availability in the midbrain between morbidly obese and nonobese young adults without an eating disorder indicates an unmet need for investigating the role of cerebral serotonin in obesity.
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U2 - 10.1371/journal.pone.0170886
DO - 10.1371/journal.pone.0170886
M3 - Article
C2 - 28182708
AN - SCOPUS:85012078066
SN - 1932-6203
VL - 12
JO - PloS one
JF - PloS one
IS - 2
M1 - 0170886
ER -