Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine

Li Wei Cheng, Sheng Wen Huang, Li Min Huang, Luan Yin Chang, Pei Lan Shao, David Kiang, Jen Ren Wang

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Evaluation of the efficacy of influenza vaccines is essential for vaccine development. This study evaluated the neutralizing and hemagglutination-inhibition antibody response in subjects receiving the 2006-07 and 2007-08 seasonal influenza vaccines. ELISA-based microneutralization demonstrated a greater mean-fold increase and seroconversion rate than the hemagglutination-inhibition assay. The increase in the antibody titers against influenza H1 were higher than those against influenza H3 and influenza B, indicating that the H1 vaccine strain in the 2006-07 and 2007-08 seasons was more immunogenic. These data suggest that the neutralizing antibody response is a better measurement of influenza vaccine efficacy.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalJournal of Virological Methods
Volume182
Issue number1-2
DOIs
Publication statusPublished - 2012 Jun 1

All Science Journal Classification (ASJC) codes

  • Virology

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