Comparison of ofloxacin and norfloxacin concentration in prostatic tissues in patients undergoing transurethral resection of the prostate

J. Chen, R. R.L. Chen, Ho-Shiang Huang

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2 Citations (Scopus)

Abstract

Background and purpose: To compare the concentrations of two fluoroquinolones, ofloxacin (OFLX) and norfloxacin (NFLX), in the prostate glands of patients who underwent transurethral resection of the prostate (TUR-P) after oral ingestion of both drugs for surgical prophylaxis. Methods: Ten patients with clinical symptoms of benign prostatic hyperplasia undergoing TUR-P received 200 mg of both drugs per os simultaneously 2 hours before surgery. The concentrations of the drugs in the serum and prostate at the time of surgery were measured by high performance liquid chromatography. Patients' clinical characteristics were evaluated, including findings from transrectal ultrasonography of the prostate, prostate specific antigen concentration, renal function tests, and post-operative status. Results: Two hours after administration, the mean serum concentration of OFLX was 4.14 ± 0.64 mg/L (range 0.27-6.37) and of NFLX was 1.10 ± 0.22 mg/L (range 0.02-2.1). The concentration of ORLX in prostatic tissue was 4.10 ± 0.79 μg/g (range 1.70-6.37) and of NFLX was 2.22±0.57 μg/g (range 0.63-4.35). The ratio of the prostatic tissue concentration (P) to the serum concentration (S) was 2.11 for OFLX and 5.71 for NFLX. The concentrations of both drugs exceeded the minimum inhibitory concentration (MIC) for most gram-negative organisms, but NFLX may be unable to exceed the MIC90 of Enterobacter cloacae in some individuals. Leukocytosis and spiking fever developed after TUR-P in two of the 10 patients. Conclusions: Concentrations of OFLX were higher in both serum and prostatic adenoma tissues than those of NFLX (P < 0.001), while NFLX had better penetration into the prostate (P/S ratio) (p < 0.001). The results of this study indicated that the concentrations of both of these drugs exceeded the MIC for most gram-negative organisms.

Original languageEnglish
Pages (from-to)548-552
Number of pages5
JournalJournal of the Formosan Medical Association
Volume100
Issue number8
Publication statusPublished - 2001

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Norfloxacin
Transurethral Resection of Prostate
Ofloxacin
Prostate
Pharmaceutical Preparations
Prostatic Hyperplasia
Microbial Sensitivity Tests
Serum
Enterobacter cloacae
Fluoroquinolones
Leukocytosis
Prostate-Specific Antigen
Ultrasonography
Fever
Eating
High Pressure Liquid Chromatography
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Comparison of ofloxacin and norfloxacin concentration in prostatic tissues in patients undergoing transurethral resection of the prostate",
abstract = "Background and purpose: To compare the concentrations of two fluoroquinolones, ofloxacin (OFLX) and norfloxacin (NFLX), in the prostate glands of patients who underwent transurethral resection of the prostate (TUR-P) after oral ingestion of both drugs for surgical prophylaxis. Methods: Ten patients with clinical symptoms of benign prostatic hyperplasia undergoing TUR-P received 200 mg of both drugs per os simultaneously 2 hours before surgery. The concentrations of the drugs in the serum and prostate at the time of surgery were measured by high performance liquid chromatography. Patients' clinical characteristics were evaluated, including findings from transrectal ultrasonography of the prostate, prostate specific antigen concentration, renal function tests, and post-operative status. Results: Two hours after administration, the mean serum concentration of OFLX was 4.14 ± 0.64 mg/L (range 0.27-6.37) and of NFLX was 1.10 ± 0.22 mg/L (range 0.02-2.1). The concentration of ORLX in prostatic tissue was 4.10 ± 0.79 μg/g (range 1.70-6.37) and of NFLX was 2.22±0.57 μg/g (range 0.63-4.35). The ratio of the prostatic tissue concentration (P) to the serum concentration (S) was 2.11 for OFLX and 5.71 for NFLX. The concentrations of both drugs exceeded the minimum inhibitory concentration (MIC) for most gram-negative organisms, but NFLX may be unable to exceed the MIC90 of Enterobacter cloacae in some individuals. Leukocytosis and spiking fever developed after TUR-P in two of the 10 patients. Conclusions: Concentrations of OFLX were higher in both serum and prostatic adenoma tissues than those of NFLX (P < 0.001), while NFLX had better penetration into the prostate (P/S ratio) (p < 0.001). The results of this study indicated that the concentrations of both of these drugs exceeded the MIC for most gram-negative organisms.",
author = "J. Chen and Chen, {R. R.L.} and Ho-Shiang Huang",
year = "2001",
language = "English",
volume = "100",
pages = "548--552",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Excerpta Medica Asia Ltd.",
number = "8",

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T1 - Comparison of ofloxacin and norfloxacin concentration in prostatic tissues in patients undergoing transurethral resection of the prostate

AU - Chen, J.

AU - Chen, R. R.L.

AU - Huang, Ho-Shiang

PY - 2001

Y1 - 2001

N2 - Background and purpose: To compare the concentrations of two fluoroquinolones, ofloxacin (OFLX) and norfloxacin (NFLX), in the prostate glands of patients who underwent transurethral resection of the prostate (TUR-P) after oral ingestion of both drugs for surgical prophylaxis. Methods: Ten patients with clinical symptoms of benign prostatic hyperplasia undergoing TUR-P received 200 mg of both drugs per os simultaneously 2 hours before surgery. The concentrations of the drugs in the serum and prostate at the time of surgery were measured by high performance liquid chromatography. Patients' clinical characteristics were evaluated, including findings from transrectal ultrasonography of the prostate, prostate specific antigen concentration, renal function tests, and post-operative status. Results: Two hours after administration, the mean serum concentration of OFLX was 4.14 ± 0.64 mg/L (range 0.27-6.37) and of NFLX was 1.10 ± 0.22 mg/L (range 0.02-2.1). The concentration of ORLX in prostatic tissue was 4.10 ± 0.79 μg/g (range 1.70-6.37) and of NFLX was 2.22±0.57 μg/g (range 0.63-4.35). The ratio of the prostatic tissue concentration (P) to the serum concentration (S) was 2.11 for OFLX and 5.71 for NFLX. The concentrations of both drugs exceeded the minimum inhibitory concentration (MIC) for most gram-negative organisms, but NFLX may be unable to exceed the MIC90 of Enterobacter cloacae in some individuals. Leukocytosis and spiking fever developed after TUR-P in two of the 10 patients. Conclusions: Concentrations of OFLX were higher in both serum and prostatic adenoma tissues than those of NFLX (P < 0.001), while NFLX had better penetration into the prostate (P/S ratio) (p < 0.001). The results of this study indicated that the concentrations of both of these drugs exceeded the MIC for most gram-negative organisms.

AB - Background and purpose: To compare the concentrations of two fluoroquinolones, ofloxacin (OFLX) and norfloxacin (NFLX), in the prostate glands of patients who underwent transurethral resection of the prostate (TUR-P) after oral ingestion of both drugs for surgical prophylaxis. Methods: Ten patients with clinical symptoms of benign prostatic hyperplasia undergoing TUR-P received 200 mg of both drugs per os simultaneously 2 hours before surgery. The concentrations of the drugs in the serum and prostate at the time of surgery were measured by high performance liquid chromatography. Patients' clinical characteristics were evaluated, including findings from transrectal ultrasonography of the prostate, prostate specific antigen concentration, renal function tests, and post-operative status. Results: Two hours after administration, the mean serum concentration of OFLX was 4.14 ± 0.64 mg/L (range 0.27-6.37) and of NFLX was 1.10 ± 0.22 mg/L (range 0.02-2.1). The concentration of ORLX in prostatic tissue was 4.10 ± 0.79 μg/g (range 1.70-6.37) and of NFLX was 2.22±0.57 μg/g (range 0.63-4.35). The ratio of the prostatic tissue concentration (P) to the serum concentration (S) was 2.11 for OFLX and 5.71 for NFLX. The concentrations of both drugs exceeded the minimum inhibitory concentration (MIC) for most gram-negative organisms, but NFLX may be unable to exceed the MIC90 of Enterobacter cloacae in some individuals. Leukocytosis and spiking fever developed after TUR-P in two of the 10 patients. Conclusions: Concentrations of OFLX were higher in both serum and prostatic adenoma tissues than those of NFLX (P < 0.001), while NFLX had better penetration into the prostate (P/S ratio) (p < 0.001). The results of this study indicated that the concentrations of both of these drugs exceeded the MIC for most gram-negative organisms.

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M3 - Article

VL - 100

SP - 548

EP - 552

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

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