Complex of simian virus large T antigen and p53 can bind DNA specifically

S. B. Long, H. Y. Ho, C. L. Chen, Ming-Derg Lai

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The DNA-binding activity of p53 was suggested to be abrogated by binding of large T antigen. However we demonstrate that a function of p53 can form a complex with large T antigen and still bind DNA specifically. In EMSA analysis, both PAb 416 and 419 anti-large-T antibodies could induce supershift on p53-DNA complex using extracts derived from two T-antigen-transformed cell lines. In EMSA-Western analysis, one of the p53-complexes was shown to contain large T antigen.

Original languageEnglish
Pages (from-to)1375-1380
Number of pages6
JournalAnticancer research
Volume15
Issue number4
Publication statusPublished - 1995 Jan 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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