Computer morphometry for liver fibrosis using an automatic image analysis system

Xi-Zhang Lin, Yung-Nien Sun, Ming Huwi Horng, Xiao Zhen Guo

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

Liver biopsy is the gold standard for evaluation of liver diseases. The severity of fibrosis is considered the stage of chronic liver disease. However, it is evaluated by subjective description or semiquantitation. We developed an automatic image analysis system, which including a microscope, computer-driven slide-driver, and a software system for image acquisition, processing and data analysis. The automatic image analysis system deals mainly with color image segmentation. The severity of liver fibrosis is reported as the percentage of the entire fibrous area to the whole liver tissue area. Thirty-one liver needle biopsy specimens are used for this study. The results from computer morphometry were compared with that from colorimetric method and Knodell's score. Pearson correlation and Spearman rank test revealed that the Knodell's score and colorimetric method are significantly correlated with the result of computer morphometry. We found that the system is a reliable tool for evaluating the severity of liver fibrosis.

Original languageEnglish
Pages (from-to)682-683
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
Publication statusPublished - 1996 Dec 1
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 5) - Amsterdam, Neth
Duration: 1996 Oct 311996 Nov 3

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Liver Cirrhosis
Liver
Image analysis
Liver Diseases
Needle Biopsy
Biopsy
Fibrosis
Chronic Disease
Software
Color
Image acquisition
Image segmentation
Needles
Microscopes
Computer systems
Tissue
Processing

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

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Computer morphometry for liver fibrosis using an automatic image analysis system. / Lin, Xi-Zhang; Sun, Yung-Nien; Horng, Ming Huwi; Guo, Xiao Zhen.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 2, 01.12.1996, p. 682-683.

Research output: Contribution to journalConference article

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