COMT and BDNF interacted in bipolar II disorder not comorbid with anxiety disorder

Sheng Yu Lee, Shiou Lan Chen, Yu Shan Wang, Yun Hsuan Chang, San Yuan Huang, Nian Sheng Tzeng, I. Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru Band Lu

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Bipolar disorder (BP), especially bipolar II disorder (BP-II), is highly comorbid with anxiety disorder (AD). Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes. Seven hundred and seventy-one participants were recruited: 314 with bipolar-II without AD, 117 with bipolar-II with AD, and 340 healthy controls. The genotypes of the COMT and BDNF polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 2013 Jan 15

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience


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