TY - JOUR
T1 - COMT and BDNF interacted in bipolar II disorder not comorbid with anxiety disorder
AU - Lee, Sheng Yu
AU - Chen, Shiou Lan
AU - Wang, Yu Shan
AU - Chang, Yun Hsuan
AU - Huang, San Yuan
AU - Tzeng, Nian Sheng
AU - Lee, I. Hui
AU - Yeh, Tzung Lieh
AU - Yang, Yen Kuang
AU - Lu, Ru Band
N1 - Funding Information:
This work was supported in part by grant NSC98-2314-B-006-022-MY3 (to RBL) and grant NSC 100-2314-B-006-048-MY3 (to SYL) from the Taiwan National Science Council , grant DOH 95-TD-M-113-055 (to RBL) from the Taiwan Department of Health , grant NHRI-EX-97-9738NI (to RBL) from the Taiwan National Health Research Institute , and the National Cheng Kung University Project for Promoting Academic Excellence and Developing World Class Research Centers .
PY - 2013/1/15
Y1 - 2013/1/15
N2 - Bipolar disorder (BP), especially bipolar II disorder (BP-II), is highly comorbid with anxiety disorder (AD). Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes. Seven hundred and seventy-one participants were recruited: 314 with bipolar-II without AD, 117 with bipolar-II with AD, and 340 healthy controls. The genotypes of the COMT and BDNF polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II.
AB - Bipolar disorder (BP), especially bipolar II disorder (BP-II), is highly comorbid with anxiety disorder (AD). Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes. Seven hundred and seventy-one participants were recruited: 314 with bipolar-II without AD, 117 with bipolar-II with AD, and 340 healthy controls. The genotypes of the COMT and BDNF polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II.
UR - http://www.scopus.com/inward/record.url?scp=84867597615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867597615&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2012.09.039
DO - 10.1016/j.bbr.2012.09.039
M3 - Article
C2 - 23026378
AN - SCOPUS:84867597615
SN - 0166-4328
VL - 237
SP - 243
EP - 248
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -