Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in pancreatic β-cells

Yi Wu, Show Ling Shyng, Pei Chun Chen

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Background: Leptin recruits KATP channels to the pancreatic β-cell membrane. Results: Leptin causes a parallel increase in Kv2.1 channel density that is dependent on AMPK, PKA, and actin depolymerization. Conclusion: Leptin signaling leads to simultaneous increases in KATP and Kv2.1 channel densities. Significance: Concerted KATP and Kv2.1 channel trafficking regulation by leptin may result in coordinated inhibition of β-cell excitability.

Original languageEnglish
Pages (from-to)29676-29690
Number of pages15
JournalJournal of Biological Chemistry
Issue number50
Publication statusPublished - 2015 Dec 11

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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