Congenital candidal onychomycosis - A case report

Chao Kai Hsu, Mark Ming Long Hsu, Tsung Chain Chang, Tak Wah Wong, Julia Yu Yun Lee, Ching Chuan Liu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Onychomycosis represents 40% of all nail disorders. It is commonly observed in adults but rarely in children. Candida species, although frequently isolated in many occasions, are rarely proved to be the causative agent in the disease. Here we present a male infant who presented with congenital candidal onychomycosis since 1 week of age. He was born to a 33-year-old healthy woman (gravida 2 para 2) via normal vaginal delivery at 36th week of gestation. Before childbirth, the mother had a history of vaginal discharge, from which the bacterial culture showed yeast-like microorganism in moderate amount. On examination, the neonate had no evidence of mucosal and cutaneous candidiasis except yellowish discoloration and thickening of the fingernails and toenails with inflammation of the periungual area. The KOH preparation from nails revealed a large number of pseudohyphae. The fungal culture revealed the presence of Candida albicans. Histopathologically, the nail clipping showed numerous PAS-positive hyphal elements. In addition, ribosomal internal transcribed spacer (ITS) amplified by PCR from nail clippings hybridized only with Candida albicans-specific oligonucleotide probe immobilized on a DNA chip which contained an array of oligonucleotides of detection of yeasts and dermatophytes. The patient received topical sulconazole nitrate 1% solution for 2 months, which led to cure of infected fingernails.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalDermatologica Sinica
Volume25
Issue number3
Publication statusPublished - 2007 Sep

All Science Journal Classification (ASJC) codes

  • Dermatology

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