Conjunctival geographic ulcer: An overlooked sign of herpes simplex virus infection

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Herpes simplex virus (HSV) ocular infection causes significant visual burden worldwide. Despite the fact that dendritic or geographic corneal ulcers are typical findings in HSV epithelial keratitis, conjunctival ulcer as a sign of HSV infection has rarely been reported. Although easily overlooked, this important sign could be enhanced by fluorescein staining. We report two cases of conjunctival geographic ulcers proven to be HSV infection by viral isolation and polymerase chain reaction (PCR). One patient had bilateral disease and blepharitis, and the other had unilateral involvement without skin lesions. With timely diagnosis and proper management, excellent visual outcome can be expected.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalJournal of Clinical Virology
Volume64
DOIs
Publication statusPublished - 2015 Mar 1

Fingerprint

Virus Diseases
Simplexvirus
Ulcer
Blepharitis
Corneal Ulcer
Eye Infections
Keratitis
Fluorescein
Staining and Labeling
Polymerase Chain Reaction
Skin

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

@article{d989d4747c5d482c87d2de9bcd04d1c1,
title = "Conjunctival geographic ulcer: An overlooked sign of herpes simplex virus infection",
abstract = "Herpes simplex virus (HSV) ocular infection causes significant visual burden worldwide. Despite the fact that dendritic or geographic corneal ulcers are typical findings in HSV epithelial keratitis, conjunctival ulcer as a sign of HSV infection has rarely been reported. Although easily overlooked, this important sign could be enhanced by fluorescein staining. We report two cases of conjunctival geographic ulcers proven to be HSV infection by viral isolation and polymerase chain reaction (PCR). One patient had bilateral disease and blepharitis, and the other had unilateral involvement without skin lesions. With timely diagnosis and proper management, excellent visual outcome can be expected.",
author = "Jia-Horung Hung and Chu, {Chang Yao} and Lee, {Chaw Ning} and Chao-Kai Hsu and Yu-Yun Lee and Jen-Ren Wang and Kung-Chao Chang and Fu-Chin Huang",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.jcv.2015.01.002",
language = "English",
volume = "64",
pages = "40--44",
journal = "Journal of Clinical Virology",
issn = "1386-6532",
publisher = "Elsevier",

}

TY - JOUR

T1 - Conjunctival geographic ulcer

T2 - An overlooked sign of herpes simplex virus infection

AU - Hung, Jia-Horung

AU - Chu, Chang Yao

AU - Lee, Chaw Ning

AU - Hsu, Chao-Kai

AU - Lee, Yu-Yun

AU - Wang, Jen-Ren

AU - Chang, Kung-Chao

AU - Huang, Fu-Chin

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Herpes simplex virus (HSV) ocular infection causes significant visual burden worldwide. Despite the fact that dendritic or geographic corneal ulcers are typical findings in HSV epithelial keratitis, conjunctival ulcer as a sign of HSV infection has rarely been reported. Although easily overlooked, this important sign could be enhanced by fluorescein staining. We report two cases of conjunctival geographic ulcers proven to be HSV infection by viral isolation and polymerase chain reaction (PCR). One patient had bilateral disease and blepharitis, and the other had unilateral involvement without skin lesions. With timely diagnosis and proper management, excellent visual outcome can be expected.

AB - Herpes simplex virus (HSV) ocular infection causes significant visual burden worldwide. Despite the fact that dendritic or geographic corneal ulcers are typical findings in HSV epithelial keratitis, conjunctival ulcer as a sign of HSV infection has rarely been reported. Although easily overlooked, this important sign could be enhanced by fluorescein staining. We report two cases of conjunctival geographic ulcers proven to be HSV infection by viral isolation and polymerase chain reaction (PCR). One patient had bilateral disease and blepharitis, and the other had unilateral involvement without skin lesions. With timely diagnosis and proper management, excellent visual outcome can be expected.

UR - http://www.scopus.com/inward/record.url?scp=84923339885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923339885&partnerID=8YFLogxK

U2 - 10.1016/j.jcv.2015.01.002

DO - 10.1016/j.jcv.2015.01.002

M3 - Article

C2 - 25728077

AN - SCOPUS:84923339885

VL - 64

SP - 40

EP - 44

JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

SN - 1386-6532

ER -