Connecting chemical exposome to human health using high-resolution mass spectrometry-based biomonitoring: Recent advances and future perspectives

Yuan Chih Chen, Jing Fang Hsu, Chih Wei Chang, Shih Wen Li, Ya Chi Yang, Mu Rong Chao, Hauh Jyun C. Chen, Pao Chi Liao

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Compared with the rapid advances in genomics leading to broad understanding of human disease, the linkage between chemical exposome and diseases is still under investigation. High-resolution mass spectrometry (HRMS) is expected to accelerate the process via relatively accurate and precise biomonitoring of human exposome. This review covers recent advancements in biomonitoring of exposed environmental chemicals (chemical exposome) using HRMS described in the 124 articles that resulted from a systematic literature search on Medline and Web of Science databases. The analytical strategic aspects, including the selection of specimens, sample preparation, instrumentation, untargeted versus targeted analysis, and workflows for MS-based biomonitoring to explore the environmental chemical space of human exposome, are deliberated. Applications of HRMS in human exposome investigation are presented by biomonitoring (1) exposed chemical compounds and their biotransformation products; (2) DNA/protein adducts; and (3) endogenous compound perturbations. Challenges and future perspectives are also discussed.

Original languageEnglish
Pages (from-to)2466-2486
Number of pages21
JournalMass Spectrometry Reviews
Volume42
Issue number6
DOIs
Publication statusPublished - 2023 Nov 1

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Analytical Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • Spectroscopy

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