Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale

Bor-Shyang Sheu, Ming Shiang Wu, Cheng Tang Chiu, Jing Chuan Lo, Deng Chyang Wu, Jyh Ming Liou, Chun Ying Wu, Hsiu-Chi Cheng, Yi Chia Lee, Ping I. Hsu, Chun Chao Chang, Wei-Lun Chang, Jaw Town Lin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80% of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.

Original languageEnglish
Article numbere12368
JournalHelicobacter
Volume22
Issue number3
DOIs
Publication statusPublished - 2017 Jun 1

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Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Taiwan
Chemoprevention
Politics
Endoscopy
Cost-Benefit Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Infectious Diseases

Cite this

Sheu, Bor-Shyang ; Wu, Ming Shiang ; Chiu, Cheng Tang ; Lo, Jing Chuan ; Wu, Deng Chyang ; Liou, Jyh Ming ; Wu, Chun Ying ; Cheng, Hsiu-Chi ; Lee, Yi Chia ; Hsu, Ping I. ; Chang, Chun Chao ; Chang, Wei-Lun ; Lin, Jaw Town. / Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale. In: Helicobacter. 2017 ; Vol. 22, No. 3.
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title = "Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale",
abstract = "Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80{\%} of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.",
author = "Bor-Shyang Sheu and Wu, {Ming Shiang} and Chiu, {Cheng Tang} and Lo, {Jing Chuan} and Wu, {Deng Chyang} and Liou, {Jyh Ming} and Wu, {Chun Ying} and Hsiu-Chi Cheng and Lee, {Yi Chia} and Hsu, {Ping I.} and Chang, {Chun Chao} and Wei-Lun Chang and Lin, {Jaw Town}",
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Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale. / Sheu, Bor-Shyang; Wu, Ming Shiang; Chiu, Cheng Tang; Lo, Jing Chuan; Wu, Deng Chyang; Liou, Jyh Ming; Wu, Chun Ying; Cheng, Hsiu-Chi; Lee, Yi Chia; Hsu, Ping I.; Chang, Chun Chao; Chang, Wei-Lun; Lin, Jaw Town.

In: Helicobacter, Vol. 22, No. 3, e12368, 01.06.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale

AU - Sheu, Bor-Shyang

AU - Wu, Ming Shiang

AU - Chiu, Cheng Tang

AU - Lo, Jing Chuan

AU - Wu, Deng Chyang

AU - Liou, Jyh Ming

AU - Wu, Chun Ying

AU - Cheng, Hsiu-Chi

AU - Lee, Yi Chia

AU - Hsu, Ping I.

AU - Chang, Chun Chao

AU - Chang, Wei-Lun

AU - Lin, Jaw Town

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80% of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.

AB - Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80% of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.

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