This study presents design considerations for a hypersonic flight test, where a primary or tertiary payload includes a single or multiple experiments to explore fluid-thermal-structural-interactions. This multi-physics problem remains a state-of-the-art research area, with greater emphasis being placed on understanding its role on the performance and survivability of hypersonic vehicles. This paper provides an overview of fluid-thermal-structural-interactions in hypersonic flight, and presents the current approaches being employed to further understand the problem. The need for a dedicated flight test is discussed, and measured against achievements that could be produced through successive tertiary experiments on flight tests focusing on other problems. Previous methods to instrument hypersonic flight-tests are examined, and potential methods to instrument an FTSI focused test are proposed.