Constituents from the fruiting bodies of trametes cubensis and trametes suaveolens in Vietnam and their anti-inflammatory bioactivity

Yue Chiun Li, Nguyen Thi Ngan, Kun Ching Cheng, Tsong Long Hwang, Tran Dinh Thang, Nguyen Ngoc Tuan, Mei Lin Yang, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

Abstract

It is reported that various fungi have been used for medicine and edible foods. The tropical Trametes genus is popular and well-known in Vietnam for its health effects and bioactivities. In this study, the fruiting bodies of the edible fungi T. cubensis and T. suaveolens were collected in Vietnam. The preliminary bioactivity screening data indicated that the methanol extracts of the fruiting bodies of T. cubensis and T. suaveolens displayed significant inhibition of superoxide anion generation and elastase release in human neutrophils. Therefore, the isolation and characterization were performed on these two species by a combination of chromatographic methods and spectrometric analysis. In total, twenty-four compounds were identified, and among these (1–3) were characterized by 1D-, 2D-NMR, and HRMS analytical data. In addition, the anti-inflammatory potentials of some purified compounds were examined by the cellular model for the inhibition of superoxide anion generation and elastase release in human neutrophils. Among the isolated compounds, (5,14), and (19) displayed significant anti-inflammatory potential. As the results suggest, the extracts and isolated compounds from T. cubensis and T. suaveolens are potential candidates for the further development of new anti-inflammatory lead drugs or natural healthy foods.

Original languageEnglish
Article number7311
JournalMolecules
Volume26
Issue number23
DOIs
Publication statusPublished - 2021 Dec 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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