Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen, Ping Chung Kuo, Shiow Chyn Huang, Tsong Long Hwang, Yu Yi Chan, Po Chuen Shieh, Nguyen Thi Ngan, Tran Dinh Thang, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

Original languageEnglish
Pages (from-to)96-104
Number of pages9
JournalJournal of Natural Medicines
Issue number1
Publication statusPublished - 2017 Jan 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine


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