Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen, Ping-Chung Kuo, Shiow Chyn Huang, Tsong Long Hwang, Yu Yi Chan, Po Chuen Shieh, Nguyen Thi Ngan, Tran Dinh Thang, Tian-Shung Wu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

Original languageEnglish
Pages (from-to)96-104
Number of pages9
JournalJournal of Natural Medicines
Volume71
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Clausena
Circular Dichroism
Amides
X-Ray Diffraction
Superoxides
Inhibitory Concentration 50
Anti-Inflammatory Agents
Single crystals
X ray diffraction
imperatorin
gamma-valerolactone

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Shen, De Yang ; Kuo, Ping-Chung ; Huang, Shiow Chyn ; Hwang, Tsong Long ; Chan, Yu Yi ; Shieh, Po Chuen ; Ngan, Nguyen Thi ; Thang, Tran Dinh ; Wu, Tian-Shung. / Constituents from the leaves of Clausena lansium and their anti-inflammatory activity. In: Journal of Natural Medicines. 2017 ; Vol. 71, No. 1. pp. 96-104.
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Shen, DY, Kuo, P-C, Huang, SC, Hwang, TL, Chan, YY, Shieh, PC, Ngan, NT, Thang, TD & Wu, T-S 2017, 'Constituents from the leaves of Clausena lansium and their anti-inflammatory activity', Journal of Natural Medicines, vol. 71, no. 1, pp. 96-104. https://doi.org/10.1007/s11418-016-1033-x

Constituents from the leaves of Clausena lansium and their anti-inflammatory activity. / Shen, De Yang; Kuo, Ping-Chung; Huang, Shiow Chyn; Hwang, Tsong Long; Chan, Yu Yi; Shieh, Po Chuen; Ngan, Nguyen Thi; Thang, Tran Dinh; Wu, Tian-Shung.

In: Journal of Natural Medicines, Vol. 71, No. 1, 01.01.2017, p. 96-104.

Research output: Contribution to journalArticle

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AU - Shieh, Po Chuen

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AU - Wu, Tian-Shung

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