Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen; Ping Chung Kuo; Shiow Chyn Huang; Tsong Long Hwang; Yu Yi Chan; Po Chuen Shieh; Nguyen Thi Ngan; Tran Dinh Thang; Tian Shung Wu

doi:10.1007/s11418-016-1033-x

Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen
, Ping Chung Kuo
, Shiow Chyn Huang
, Tsong Long Hwang
, Yu Yi Chan
, Po Chuen Shieh
, Nguyen Thi Ngan
, Tran Dinh Thang
, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC₅₀ values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

Original language	English
Pages (from-to)	96-104
Number of pages	9
Journal	Journal of Natural Medicines
Volume	71
Issue number	1
DOIs	https://doi.org/10.1007/s11418-016-1033-x
Publication status	Published - 2017 Jan 1

All Science Journal Classification (ASJC) codes

Drug Discovery
Complementary and alternative medicine
Pharmaceutical Science
Organic Chemistry

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10.1007/s11418-016-1033-x

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title = "Constituents from the leaves of Clausena lansium and their anti-inflammatory activity",

abstract = "Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.",

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AU - Shen, De Yang

AU - Kuo, Ping Chung

AU - Huang, Shiow Chyn

AU - Hwang, Tsong Long

AU - Chan, Yu Yi

AU - Shieh, Po Chuen

AU - Ngan, Nguyen Thi

AU - Thang, Tran Dinh

AU - Wu, Tian Shung

PY - 2017/1/1

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AB - Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

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Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

Abstract

All Science Journal Classification (ASJC) codes

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