Constituents from the stems of Aristolochia manshuriensis

Pei Lin Wu; Gwo Ching Su; Tian-Shung Wu

doi:10.1021/np0301238

Constituents from the stems of Aristolochia manshuriensis

Pei Lin Wu, Gwo Ching Su, Tian-Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

In a continuing search for bioactive compounds from Aristolochia species, 28 compounds, including three new constituents, demethylaristofolin E (1), aristomanoside (2), and dehydrooxoperezinone (3), were isolated from an extract of the stems of Aristolochia manshuriensis. The structures of these compounds were established by extensive 1D and 2D NMR spectral studies. Among these compounds, dehydrooxoperezinone (3) was found to inhibit the replication of HIV, with an EC₅₀ value of 17.5 μg/mL and a therapeutic index of 1.43.

Original language	English
Pages (from-to)	996-998
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	7
DOIs	https://doi.org/10.1021/np0301238
Publication status	Published - 2003 Jul 1

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np0301238

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AB - In a continuing search for bioactive compounds from Aristolochia species, 28 compounds, including three new constituents, demethylaristofolin E (1), aristomanoside (2), and dehydrooxoperezinone (3), were isolated from an extract of the stems of Aristolochia manshuriensis. The structures of these compounds were established by extensive 1D and 2D NMR spectral studies. Among these compounds, dehydrooxoperezinone (3) was found to inhibit the replication of HIV, with an EC50 value of 17.5 μg/mL and a therapeutic index of 1.43.

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Constituents from the stems of Aristolochia manshuriensis

Abstract

All Science Journal Classification (ASJC) codes

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