Constituents from Vigna vexillata and their anti-inflammatory activity

Yann Lii Leu; Tsong Long Hwang; Ping Chung Kuo; Kun Pei Liou; Bow Shin Huang; Guo Feng Chen

doi:10.3390/ijms13089754

Constituents from Vigna vexillata and their anti-inflammatory activity

Yann Lii Leu, Tsong Long Hwang, Ping Chung Kuo, Kun Pei Liou, Bow Shin Huang, Guo Feng Chen

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The seeds of Vigna genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of V. vexillata demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of V. vexillata. One new sterol (1) and two new isoflavones (2,3) were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23), abscisic acid (25), and quercetin (40) displayed the most significant inhibition of superoxide anion generation and elastase release.

Original language	English
Pages (from-to)	9754-9768
Number of pages	15
Journal	International journal of molecular sciences
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/ijms13089754
Publication status	Published - 2012 Aug

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Constituents from Vigna vexillata and their anti-inflammatory activity",

abstract = "The seeds of Vigna genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of V. vexillata demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of V. vexillata. One new sterol (1) and two new isoflavones (2,3) were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23), abscisic acid (25), and quercetin (40) displayed the most significant inhibition of superoxide anion generation and elastase release.",

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AU - Huang, Bow Shin

AU - Chen, Guo Feng

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