Constituents of leaves of phellodendron japonicum MAXIM. and their antioxidant activity

Chih Yang Chiu, Chia Ying Li, Chao Chen Chiu, Masatake Niwa, Susumu Kitanaka, Amooru Gangaiah Damu, E. Jian Lee, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Three new flavonoid derivatives, 6‴-O-acetyl amurensin (1), 6‴-O-acetyl phellamurin (3) and (2R)-phellodensin-F (5), together with thirty known compounds have been isolated from the leaves of Phellodendron japonicum MAXIM. Their structures were established by means of spectroscopic analysis, including extensive 2D NMR and Mass spectra. The known compounds were identified by comparison with published physical and spectral data. The isolated compounds were screened for their in vitro antioxidant activity through DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay. Compounds quercetin and phellodenin-A demonstrated significant radical scavenging activity.

Original languageEnglish
Pages (from-to)1118-1121
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - 2005 Sep

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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