Constituents of the fruits of Citrus medica L. var. sarcodactylis and the effect of 6,7-dimethoxy-coumarin on superoxide anion formation and elastase release

Yu Yi Chan, Tsong Long Hwang, Ping Chung Kuo, Hsin Yi Hung, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.

Original languageEnglish
Article number1454
JournalMolecules
Volume22
Issue number9
DOIs
Publication statusPublished - 2017 Sep

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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