Constituents of the fruits of Citrus medica L. var. sarcodactylis and the effect of 6,7-dimethoxy-coumarin on superoxide anion formation and elastase release

Yu Yi Chan, Tsong Long Hwang, Ping Chung Kuo, Hsin Yi Hung, Tian Shung Wu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.

Original languageEnglish
Article number1454
JournalMolecules
Volume22
Issue number9
DOIs
Publication statusPublished - 2017 Sep

Fingerprint

scoparone
fruits
Citrus
inorganic peroxides
Pancreatic Elastase
Fruits
Superoxides
Fruit
neutrophils
anions
Sesquiterpenes
Inhibitory Concentration 50
Neutrophils
Nuclear magnetic resonance
nuclear magnetic resonance
coumarin 7
coumarin
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

@article{70c316ebdf9e41dcb2f27b154cd8b0de,
title = "Constituents of the fruits of Citrus medica L. var. sarcodactylis and the effect of 6,7-dimethoxy-coumarin on superoxide anion formation and elastase release",
abstract = "Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.",
author = "Chan, {Yu Yi} and Hwang, {Tsong Long} and Kuo, {Ping Chung} and Hung, {Hsin Yi} and Wu, {Tian Shung}",
year = "2017",
month = "9",
doi = "10.3390/molecules22091454",
language = "English",
volume = "22",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

Constituents of the fruits of Citrus medica L. var. sarcodactylis and the effect of 6,7-dimethoxy-coumarin on superoxide anion formation and elastase release. / Chan, Yu Yi; Hwang, Tsong Long; Kuo, Ping Chung; Hung, Hsin Yi; Wu, Tian Shung.

In: Molecules, Vol. 22, No. 9, 1454, 09.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Constituents of the fruits of Citrus medica L. var. sarcodactylis and the effect of 6,7-dimethoxy-coumarin on superoxide anion formation and elastase release

AU - Chan, Yu Yi

AU - Hwang, Tsong Long

AU - Kuo, Ping Chung

AU - Hung, Hsin Yi

AU - Wu, Tian Shung

PY - 2017/9

Y1 - 2017/9

N2 - Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.

AB - Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.

UR - http://www.scopus.com/inward/record.url?scp=85029618902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029618902&partnerID=8YFLogxK

U2 - 10.3390/molecules22091454

DO - 10.3390/molecules22091454

M3 - Article

C2 - 28862688

AN - SCOPUS:85029618902

VL - 22

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 9

M1 - 1454

ER -