Constituents of the root bark of Severinia buxifolia collected in Hainan

T. S. Wu; C. M. Chen; F. W. Lin

doi:10.1021/np0005309

Constituents of the root bark of Severinia buxifolia collected in Hainan

T. S. Wu, C. M. Chen, F. W. Lin

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Two new tetranortriterpenoids, 7-isovaleroylcycloseverinolide (1) and 7-isovaleroylcycloepiatalantin (2), together with 28 known compounds, were isolated and characterized from the root bark of Severinia buxifolia collected in Hainan. The structures of 1 and 2 were elucidated on the basis of spectral evidence including 2D NMR and X-ray techniques. The cytotoxicity of several acridone alkaloid isolates (3-8) was evaluated against a small tumor cell panel.

Original language	English
Pages (from-to)	1040-1043
Number of pages	4
Journal	Journal of Natural Products
Volume	64
Issue number	8
DOIs	https://doi.org/10.1021/np0005309
Publication status	Published - 2001

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np0005309

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AB - Two new tetranortriterpenoids, 7-isovaleroylcycloseverinolide (1) and 7-isovaleroylcycloepiatalantin (2), together with 28 known compounds, were isolated and characterized from the root bark of Severinia buxifolia collected in Hainan. The structures of 1 and 2 were elucidated on the basis of spectral evidence including 2D NMR and X-ray techniques. The cytotoxicity of several acridone alkaloid isolates (3-8) was evaluated against a small tumor cell panel.

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Constituents of the root bark of Severinia buxifolia collected in Hainan

Abstract

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