Constituents of Vittaria anguste-elongata and their biological activities

Pei Lin Wu, Yu Lin Hsu, Chen Wei Zao, Amooru G. Damu, Tian-Shung Wu

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Twelve new compounds, vittarin-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), 3-O-acetylniduloic acid (7), ethyl 3-O-acetylniduloate (8), methyl 4-O-coumaroylquinate (9), vittarilide-A (10), and -B (11), and vittariflavone (12), as well as 20 known compounds have been isolated from the whole plant of Vittaria anguste-elongata. The structures of these compounds were determined by spectroscopic and chemical transformation methods. 5,7-Dihydroxy-3′, 4′,5′-trimethoxyflavone (18) displayed moderate cytotoxicity against human lung carcinoma and central nervous system carcinoma cell lines with inhibition of 89 and 61% at a concentration of 58 μM, respectively. Vittarilide-A (10) and -B (11) and ethyl 4-O-caffeoylquinate (14) exhibited moderate DPPH radical scavenging activity with IC50 values of 91, 290, and 234 μM, respectively.

Original languageEnglish
Pages (from-to)1180-1184
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number8
DOIs
Publication statusPublished - 2005 Aug 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Wu, P. L., Hsu, Y. L., Zao, C. W., Damu, A. G., & Wu, T-S. (2005). Constituents of Vittaria anguste-elongata and their biological activities. Journal of Natural Products, 68(8), 1180-1184. https://doi.org/10.1021/np050060o