Construct validity of the stroke-specific quality of life questionnaire in ischemic stroke patients

I. Ping Hsueh, Jiann Shing Jeng, Yen Lee, Ching-Fan Sheu, Ching Lin Hsieh

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Hsueh I-P, Jeng J-S, Lee Y, Sheu C-F, Hsieh C-L. Construct validity of the Stroke-Specific Quality of Life questionnaire in ischemic stroke patients. Objectives: To investigate the construct validity of the commonly used 8- and 12-domain versions of the Stroke-Specific Quality of Life (SS-QOL) with a first-order factor model. The better-fitted version was further evaluated by a second-order factor structure model in order to determine whether a summary score is justified. Design: Cohort study. Setting: Outpatient stroke clinic. Participants: Patients (N=388) with ischemic stroke. Intervention: Not applicable. Main Outcome Measures: The SS-QOL. We first conducted confirmatory factor analysis (CFA) to evaluate the construct validity of the first-order 8- or 12-domain versions of the SS-QOL. The better-fitted version was then validated by investigating the second-order health-related quality of life (HRQOL) factor. Results: The 12-domain version, but not the 8-domain version, had sufficient goodness of fit (χ2=2041.7, df=1061, χ2/df=1.9, comparative fit index [CFI]=0.98, Tucker-Lewis index [TLI]=0.98, and root mean square error of approximation=0.05). All items of the 12-domain version showed acceptable factor loadings (>0.40) and were retained. Furthermore, the second-order CFA fit indices of the 12 domains were acceptable (χ2=2630.3, df=1115, χ2/df=2.4, CFI=0.97, TLI=0.97, root mean square error of approximation=0.06), indicating that a summary score was justified for representing the overall status of HRQOL. Conclusions: Our results show that the construct validity of the 12-domain SS-QOL is well supported for measuring HRQOL in ischemic stroke patients. Thus, we recommend the 12-domain version of the SS-QOL for use in capturing the multiple impacts of stroke as well as overall HRQOL status on the basis of patients' perspectives.

Original languageEnglish
Pages (from-to)1113-1118
Number of pages6
JournalArchives of Physical Medicine and Rehabilitation
Issue number7
Publication statusPublished - 2011 Jul 1


All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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