Continuous production of algicidal compounds against Akashiwo sanguinea via a Vibrio sp. co-culture

Yue Wang, Shuangfei Li, Guozhu Liu, Xiaoqiang Li, Qixia Yang, Ying Xu, Zhangli Hu, Chun Yen Chen, Jo Shu Chang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Using biological treatment to deal with harmful algal blooms is highly potential over the physical and chemical methods due to its species specificity and eco-friendly characteristics. In this study, algicidal broth were produced from a Vibrio sp. co-culture composed mainly of V. brasilliensis and V. tubiashii. The productivity of the algicidal compounds was optimized under a dilution rate of 0.1 h−1 with a minimum algicidal broth dosage of 0.3% for 100% algal lysis. The algicidal threshold and EC50 of the spray-dried algicidal broth were 0.17 and 0.68 g/L, respectively. Treatment with the algicidal agents led to an increase in cellular reactive oxygen species (ROS) level that causes membrane damage as supported by the increase in Malondialdehyde (MDA) levels. and a further inhibition to the antioxidant system as indicated by a sharp decrease in the catalase (CAT) activity. The algicidal compound was identified as hexahydro pyrrolo[1,2-a] pyr azine-1,4-dione.

Original languageEnglish
Article number122246
JournalBioresource technology
Publication statusPublished - 2020 Jan

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal

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