Continuous wave spectroscopy with diffusion theory for quantification of optical properties

Comparison between multi-distance and multi-wavelength data fitting methods

Yung Chi Lin, Zhi Fong Lin, Shoko Nioka, Li Hsin Chen, Sheng-Hao Tseng, Pau-Choo Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Typically, continuous wave spectroscopy (CWS) can be used to accurately quantify biological tissue optical properties (μa and μs ′) by employing the diffuse reflectance information acquired at multiple source-detector separations (multi-distance). On the other hand, sample optical properties can also be obtained by fitting multi-wavelength light reflectance acquired at a single source detector separation to the diffusion theory equation. To date, multi-wavelength and multidistance methods have not yet been rigorously compared for their accuracy in quantification of the sample optical properties. In this investigation, we compared the accuracy of the two above-mentioned quantifying methods in the optical properties recovery. The liquid phantoms had μa between 0.004 and 0.011 mm−1 and μs ′ between 0.55 and 1.07 mm−1 whose optical properties mimic the human breast. Multi-distance data and multi-wavelength data were fitted to the same diffusion equation for consistency. The difference between benchmark μa and μs ′ and the fitted results, ΔError (ΔE) was used to evaluate the accuracy of the two methods. The results showed that either method yielded Δ E within 15–30 % when values were within certain limits to standard values applicable to μs ′ and μa for human adipose tissue. Both methods showed no significant differences in Δ E values. Our results suggest that both multidistance and multi-wavelength methods can yield similar reasonable optical properties in biological tissue with a proper calibration.

Original languageEnglish
Title of host publicationOxygen Transport to Tissue XXXVIII
EditorsDuane F. Bruley, Qingming Luo, Lin Z. Li, Hua Shi, David K. Harrison, Duane F. Bruley
PublisherSpringer New York LLC
Pages337-343
Number of pages7
ISBN (Print)9783319388083
DOIs
Publication statusPublished - 2016 Jan 1
Event43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015 - Wuhan, China
Duration: 2015 Jul 112015 Jul 16

Publication series

NameAdvances in Experimental Medicine and Biology
Volume923
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Other

Other43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015
CountryChina
CityWuhan
Period15-07-1115-07-16

Fingerprint

Spectrum Analysis
Optical properties
Spectroscopy
Wavelength
Tissue
Detectors
Benchmarking
Calibration
Light sources
Adipose Tissue
Breast
Light
Recovery
Liquids

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lin, Y. C., Lin, Z. F., Nioka, S., Chen, L. H., Tseng, S-H., & Chung, P-C. (2016). Continuous wave spectroscopy with diffusion theory for quantification of optical properties: Comparison between multi-distance and multi-wavelength data fitting methods. In D. F. Bruley, Q. Luo, L. Z. Li, H. Shi, D. K. Harrison, & D. F. Bruley (Eds.), Oxygen Transport to Tissue XXXVIII (pp. 337-343). (Advances in Experimental Medicine and Biology; Vol. 923). Springer New York LLC. https://doi.org/10.1007/978-3-319-38810-6_44
Lin, Yung Chi ; Lin, Zhi Fong ; Nioka, Shoko ; Chen, Li Hsin ; Tseng, Sheng-Hao ; Chung, Pau-Choo. / Continuous wave spectroscopy with diffusion theory for quantification of optical properties : Comparison between multi-distance and multi-wavelength data fitting methods. Oxygen Transport to Tissue XXXVIII. editor / Duane F. Bruley ; Qingming Luo ; Lin Z. Li ; Hua Shi ; David K. Harrison ; Duane F. Bruley. Springer New York LLC, 2016. pp. 337-343 (Advances in Experimental Medicine and Biology).
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title = "Continuous wave spectroscopy with diffusion theory for quantification of optical properties: Comparison between multi-distance and multi-wavelength data fitting methods",
abstract = "Typically, continuous wave spectroscopy (CWS) can be used to accurately quantify biological tissue optical properties (μa and μs ′) by employing the diffuse reflectance information acquired at multiple source-detector separations (multi-distance). On the other hand, sample optical properties can also be obtained by fitting multi-wavelength light reflectance acquired at a single source detector separation to the diffusion theory equation. To date, multi-wavelength and multidistance methods have not yet been rigorously compared for their accuracy in quantification of the sample optical properties. In this investigation, we compared the accuracy of the two above-mentioned quantifying methods in the optical properties recovery. The liquid phantoms had μa between 0.004 and 0.011 mm−1 and μs ′ between 0.55 and 1.07 mm−1 whose optical properties mimic the human breast. Multi-distance data and multi-wavelength data were fitted to the same diffusion equation for consistency. The difference between benchmark μa and μs ′ and the fitted results, ΔError (ΔE) was used to evaluate the accuracy of the two methods. The results showed that either method yielded Δ E within 15–30 {\%} when values were within certain limits to standard values applicable to μs ′ and μa for human adipose tissue. Both methods showed no significant differences in Δ E values. Our results suggest that both multidistance and multi-wavelength methods can yield similar reasonable optical properties in biological tissue with a proper calibration.",
author = "Lin, {Yung Chi} and Lin, {Zhi Fong} and Shoko Nioka and Chen, {Li Hsin} and Sheng-Hao Tseng and Pau-Choo Chung",
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Lin, YC, Lin, ZF, Nioka, S, Chen, LH, Tseng, S-H & Chung, P-C 2016, Continuous wave spectroscopy with diffusion theory for quantification of optical properties: Comparison between multi-distance and multi-wavelength data fitting methods. in DF Bruley, Q Luo, LZ Li, H Shi, DK Harrison & DF Bruley (eds), Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol. 923, Springer New York LLC, pp. 337-343, 43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015, Wuhan, China, 15-07-11. https://doi.org/10.1007/978-3-319-38810-6_44

Continuous wave spectroscopy with diffusion theory for quantification of optical properties : Comparison between multi-distance and multi-wavelength data fitting methods. / Lin, Yung Chi; Lin, Zhi Fong; Nioka, Shoko; Chen, Li Hsin; Tseng, Sheng-Hao; Chung, Pau-Choo.

Oxygen Transport to Tissue XXXVIII. ed. / Duane F. Bruley; Qingming Luo; Lin Z. Li; Hua Shi; David K. Harrison; Duane F. Bruley. Springer New York LLC, 2016. p. 337-343 (Advances in Experimental Medicine and Biology; Vol. 923).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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T1 - Continuous wave spectroscopy with diffusion theory for quantification of optical properties

T2 - Comparison between multi-distance and multi-wavelength data fitting methods

AU - Lin, Yung Chi

AU - Lin, Zhi Fong

AU - Nioka, Shoko

AU - Chen, Li Hsin

AU - Tseng, Sheng-Hao

AU - Chung, Pau-Choo

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N2 - Typically, continuous wave spectroscopy (CWS) can be used to accurately quantify biological tissue optical properties (μa and μs ′) by employing the diffuse reflectance information acquired at multiple source-detector separations (multi-distance). On the other hand, sample optical properties can also be obtained by fitting multi-wavelength light reflectance acquired at a single source detector separation to the diffusion theory equation. To date, multi-wavelength and multidistance methods have not yet been rigorously compared for their accuracy in quantification of the sample optical properties. In this investigation, we compared the accuracy of the two above-mentioned quantifying methods in the optical properties recovery. The liquid phantoms had μa between 0.004 and 0.011 mm−1 and μs ′ between 0.55 and 1.07 mm−1 whose optical properties mimic the human breast. Multi-distance data and multi-wavelength data were fitted to the same diffusion equation for consistency. The difference between benchmark μa and μs ′ and the fitted results, ΔError (ΔE) was used to evaluate the accuracy of the two methods. The results showed that either method yielded Δ E within 15–30 % when values were within certain limits to standard values applicable to μs ′ and μa for human adipose tissue. Both methods showed no significant differences in Δ E values. Our results suggest that both multidistance and multi-wavelength methods can yield similar reasonable optical properties in biological tissue with a proper calibration.

AB - Typically, continuous wave spectroscopy (CWS) can be used to accurately quantify biological tissue optical properties (μa and μs ′) by employing the diffuse reflectance information acquired at multiple source-detector separations (multi-distance). On the other hand, sample optical properties can also be obtained by fitting multi-wavelength light reflectance acquired at a single source detector separation to the diffusion theory equation. To date, multi-wavelength and multidistance methods have not yet been rigorously compared for their accuracy in quantification of the sample optical properties. In this investigation, we compared the accuracy of the two above-mentioned quantifying methods in the optical properties recovery. The liquid phantoms had μa between 0.004 and 0.011 mm−1 and μs ′ between 0.55 and 1.07 mm−1 whose optical properties mimic the human breast. Multi-distance data and multi-wavelength data were fitted to the same diffusion equation for consistency. The difference between benchmark μa and μs ′ and the fitted results, ΔError (ΔE) was used to evaluate the accuracy of the two methods. The results showed that either method yielded Δ E within 15–30 % when values were within certain limits to standard values applicable to μs ′ and μa for human adipose tissue. Both methods showed no significant differences in Δ E values. Our results suggest that both multidistance and multi-wavelength methods can yield similar reasonable optical properties in biological tissue with a proper calibration.

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Lin YC, Lin ZF, Nioka S, Chen LH, Tseng S-H, Chung P-C. Continuous wave spectroscopy with diffusion theory for quantification of optical properties: Comparison between multi-distance and multi-wavelength data fitting methods. In Bruley DF, Luo Q, Li LZ, Shi H, Harrison DK, Bruley DF, editors, Oxygen Transport to Tissue XXXVIII. Springer New York LLC. 2016. p. 337-343. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-38810-6_44