Copper-Catalyzed Decarboxylative Difluoromethylation

Xiaojun Zeng, Wenhao Yan, Samson B. Zacate, Tzu Hsuan Chao, Xiaodong Sun, Zhi Cao, Kate G.E. Bradford, Matthew Paeth, Sam B. Tyndall, Kundi Yang, Tung Chun Kuo, Mu Jeng Cheng, Wei Liu

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products. Mechanistic studies support the involvement of alkyl radicals.

Original languageEnglish
Pages (from-to)11398-11403
Number of pages6
JournalJournal of the American Chemical Society
Issue number29
Publication statusPublished - 2019 Jul 24

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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