Copper sulfide nanodisk as photoacoustic contrast agent for ovarian tumor detection

Junxin Wang, Su Wen Hsu, Andrea R. Tao, Jesse V. Jokerst

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ultrasound is broadly used in the clinics yet is limited in early cancer detection because of its poor contrast between healthy and diseased tissues. Photoacoustic imaging can improve this limitation and has been extensively studied in pre-clinical models. Contrast agents can help improve the accuracy of diagnosis. We recently reported a novel copper sulfide (CuS) nanodisk with strong directionally-localized surface plasmon resonance in the near infrared region. This plasmonic resonance of nanodisks is tunable by changing the size and aspect ratio of CuS nanodisk. Here, we demonstrate this CuS nanodisk is a strong photoacoustic contrast agent. We prepared CuS nanodisks via a solvent-based synthesis followed by surface modification of poly(ethylene glycol) methyl ether thiol for in vivo applications. These CuS nanodisks can be detected at a concentration as low as 26 pM at 920 nm. Their nanosize and strong photoacoustic response make this novel CuS nanodisk a strong candidate for photoacoustic cancer imaging.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2017
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510605695
DOIs
Publication statusPublished - 2017 Jan 1
EventPhotons Plus Ultrasound: Imaging and Sensing 2017 - San Francisco, United States
Duration: 2017 Jan 292017 Feb 1

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10064
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2017
CountryUnited States
CitySan Francisco
Period17-01-2917-02-01

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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