Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging

Junxin Wang, Su wen Hsu, Natalia Gonzalez-Pech, Anamik Jhunjhunwala, Fang Chen, Ali Hariri, Vicki Grassian, Andrea Tao, Jesse V. Jokerst

Research output: Contribution to journalArticle

Abstract

Transvaginal ultrasound is widely used for ovarian cancer screening but has a high false-positive rate. Photoacoustic imaging provides additional optical contrast to supplement ultrasound and might be able to improve the accuracy of screening. Two copper sulfide (CuS) nanoparticle types (nanodisks and triangular nanoprisms) are reported as photoacoustic contrast agents for imaging ovarian cancer. Both CuS nanoprisms and nanodisks are ≈6 nm thick and ≈26 nm wide and are coated with poly(ethylene glycol) to make them colloidally stable in phosphate-buffered saline for at least two weeks. The CuS nanodisks and nanoprisms reveal strong localized surface plasmon resonances with peak maxima at 1145 and 1098 nm, respectively. Both nanoparticle types have strong and stable photoacoustic intensity with detection limits below 120 pm. The circular CuS nanodisk remains in the circulation of nude mice (n = 4) and xenograft 2008 ovarian tumors (n = 4) 17.9-fold and 1.8-fold more than the triangular nanoprisms, respectively. Finally, the photoacoustic intensity of the tumors from the mice (n = 3) treated with CuS nanodisks is threefold higher than the baseline. The tumors treated with nanodisks have a characteristic peak at 920 nm in their spectrum to potentially differentiate the tumor from adjacent tissues.

Original languageEnglish
Article number1900171
JournalParticle and Particle Systems Characterization
Volume36
Issue number8
DOIs
Publication statusPublished - 2019 Jan 1

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copper sulfides
Photoacoustic effect
Sulfides
Tumors
Copper
tumors
Imaging techniques
mice
Screening
screening
Ultrasonics
cancer
Nanoparticles
nanoparticles
Surface plasmon resonance
supplements
surface plasmon resonance
Polyethylene glycols
glycols
phosphates

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Wang, J., Hsu, S. W., Gonzalez-Pech, N., Jhunjhunwala, A., Chen, F., Hariri, A., ... Jokerst, J. V. (2019). Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging. Particle and Particle Systems Characterization, 36(8), [1900171]. https://doi.org/10.1002/ppsc.201900171
Wang, Junxin ; Hsu, Su wen ; Gonzalez-Pech, Natalia ; Jhunjhunwala, Anamik ; Chen, Fang ; Hariri, Ali ; Grassian, Vicki ; Tao, Andrea ; Jokerst, Jesse V. / Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging. In: Particle and Particle Systems Characterization. 2019 ; Vol. 36, No. 8.
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Wang, J, Hsu, SW, Gonzalez-Pech, N, Jhunjhunwala, A, Chen, F, Hariri, A, Grassian, V, Tao, A & Jokerst, JV 2019, 'Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging', Particle and Particle Systems Characterization, vol. 36, no. 8, 1900171. https://doi.org/10.1002/ppsc.201900171

Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging. / Wang, Junxin; Hsu, Su wen; Gonzalez-Pech, Natalia; Jhunjhunwala, Anamik; Chen, Fang; Hariri, Ali; Grassian, Vicki; Tao, Andrea; Jokerst, Jesse V.

In: Particle and Particle Systems Characterization, Vol. 36, No. 8, 1900171, 01.01.2019.

Research output: Contribution to journalArticle

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T1 - Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging

AU - Wang, Junxin

AU - Hsu, Su wen

AU - Gonzalez-Pech, Natalia

AU - Jhunjhunwala, Anamik

AU - Chen, Fang

AU - Hariri, Ali

AU - Grassian, Vicki

AU - Tao, Andrea

AU - Jokerst, Jesse V.

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