Corpus callosum and cerebellar vermis size in very preterm infants

Relationship to long-term neurodevelopmental outcome

Research output: Contribution to journalArticle

Abstract

Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalPediatrics and Neonatology
Volume60
Issue number2
DOIs
Publication statusPublished - 2019 Apr 1

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Corpus Callosum
Premature Infants
Cerebral Palsy
Intellectual Disability
Gestational Age
Body Weight
Periventricular Leukomalacia
Very Low Birth Weight Infant
Growth
Birth Weight
Cerebellar Vermis
Pregnancy
Brain

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{4909ad6ef12b46eaba48271cb70340a5,
title = "Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome",
abstract = "Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.",
author = "Po-Ming Wu and Hsin-I Shih and Wen-Hao Yu and Li-Wen Chen and Wang, {Lie Chuan} and Chao-Ching Huang and Yi-Fang Tu",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.pedneo.2018.05.012",
language = "English",
volume = "60",
pages = "178--185",
journal = "Pediatrics and Neonatology",
issn = "1875-9572",
publisher = "Elsevier (Singapore) Pte Ltd",
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TY - JOUR

T1 - Corpus callosum and cerebellar vermis size in very preterm infants

T2 - Relationship to long-term neurodevelopmental outcome

AU - Wu, Po-Ming

AU - Shih, Hsin-I

AU - Yu, Wen-Hao

AU - Chen, Li-Wen

AU - Wang, Lie Chuan

AU - Huang, Chao-Ching

AU - Tu, Yi-Fang

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.

AB - Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.

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DO - 10.1016/j.pedneo.2018.05.012

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JO - Pediatrics and Neonatology

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SN - 1875-9572

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