Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

Pei-Chun Hsieh, Tzung Lieh Yeh, I-Hui Lee, Hui Chun Huang, Po-See Chen, Yen-Kuang Yang, Nan-Tsing Chiu, Ru-Band Lu, Mei Hsiu Liao

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Although studies have indicated that the frontal lobe plays an important role in performance on the Wisconsin Card Sorting Test (WCST) and that basal ganglia play a specific role in frontal lobe function, the role of striatal dopamine (DA) activity in performance on the WCST remains unclear. Methods: We assessed the relation between the availability of striatal dopamine transporters (DATs) and performance on the WCST as a measure of executive function in healthy individuals. We approximated the availability of DATs in 53 healthy volunteers aged 19-61 years by use of single photon emission computed tomography with technetium-99m (99mTc)-TRODAT-1 as the ligand. The WCST was administered to all participants. Results: The availability of DAT was significantly negatively correlated with perseverative errors on the WCST, both before and after adjustment for body mass index ( rbefore = -0.39, p = 0.004; rafter = -0.39, p= 0.005). Limitations: This was an association study; thus, a causal relation between DAT availability and performance cannot be confirmed. Conclusion: Our results suggest that striatal DAT availability may play a role in executive function as measured by the WCST.

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalJournal of Psychiatry and Neuroscience
Volume35
Issue number2
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Healthy Volunteers
Executive Function
Frontal Lobe
Basal Ganglia
Single-Photon Emission-Computed Tomography
Dopamine
Body Mass Index
Ligands

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

@article{f5e7b4c6d7cd4ad7b2caa95be531a8bb,
title = "Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers",
abstract = "Background: Although studies have indicated that the frontal lobe plays an important role in performance on the Wisconsin Card Sorting Test (WCST) and that basal ganglia play a specific role in frontal lobe function, the role of striatal dopamine (DA) activity in performance on the WCST remains unclear. Methods: We assessed the relation between the availability of striatal dopamine transporters (DATs) and performance on the WCST as a measure of executive function in healthy individuals. We approximated the availability of DATs in 53 healthy volunteers aged 19-61 years by use of single photon emission computed tomography with technetium-99m (99mTc)-TRODAT-1 as the ligand. The WCST was administered to all participants. Results: The availability of DAT was significantly negatively correlated with perseverative errors on the WCST, both before and after adjustment for body mass index ( rbefore = -0.39, p = 0.004; rafter = -0.39, p= 0.005). Limitations: This was an association study; thus, a causal relation between DAT availability and performance cannot be confirmed. Conclusion: Our results suggest that striatal DAT availability may play a role in executive function as measured by the WCST.",
author = "Pei-Chun Hsieh and Yeh, {Tzung Lieh} and I-Hui Lee and Huang, {Hui Chun} and Po-See Chen and Yen-Kuang Yang and Nan-Tsing Chiu and Ru-Band Lu and Liao, {Mei Hsiu}",
year = "2010",
month = "1",
day = "1",
doi = "10.1503/jpn.090007",
language = "English",
volume = "35",
pages = "90--94",
journal = "Journal of Psychiatry and Neuroscience",
issn = "1180-4882",
publisher = "Canadian Medical Association",
number = "2",

}

TY - JOUR

T1 - Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

AU - Hsieh, Pei-Chun

AU - Yeh, Tzung Lieh

AU - Lee, I-Hui

AU - Huang, Hui Chun

AU - Chen, Po-See

AU - Yang, Yen-Kuang

AU - Chiu, Nan-Tsing

AU - Lu, Ru-Band

AU - Liao, Mei Hsiu

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Background: Although studies have indicated that the frontal lobe plays an important role in performance on the Wisconsin Card Sorting Test (WCST) and that basal ganglia play a specific role in frontal lobe function, the role of striatal dopamine (DA) activity in performance on the WCST remains unclear. Methods: We assessed the relation between the availability of striatal dopamine transporters (DATs) and performance on the WCST as a measure of executive function in healthy individuals. We approximated the availability of DATs in 53 healthy volunteers aged 19-61 years by use of single photon emission computed tomography with technetium-99m (99mTc)-TRODAT-1 as the ligand. The WCST was administered to all participants. Results: The availability of DAT was significantly negatively correlated with perseverative errors on the WCST, both before and after adjustment for body mass index ( rbefore = -0.39, p = 0.004; rafter = -0.39, p= 0.005). Limitations: This was an association study; thus, a causal relation between DAT availability and performance cannot be confirmed. Conclusion: Our results suggest that striatal DAT availability may play a role in executive function as measured by the WCST.

AB - Background: Although studies have indicated that the frontal lobe plays an important role in performance on the Wisconsin Card Sorting Test (WCST) and that basal ganglia play a specific role in frontal lobe function, the role of striatal dopamine (DA) activity in performance on the WCST remains unclear. Methods: We assessed the relation between the availability of striatal dopamine transporters (DATs) and performance on the WCST as a measure of executive function in healthy individuals. We approximated the availability of DATs in 53 healthy volunteers aged 19-61 years by use of single photon emission computed tomography with technetium-99m (99mTc)-TRODAT-1 as the ligand. The WCST was administered to all participants. Results: The availability of DAT was significantly negatively correlated with perseverative errors on the WCST, both before and after adjustment for body mass index ( rbefore = -0.39, p = 0.004; rafter = -0.39, p= 0.005). Limitations: This was an association study; thus, a causal relation between DAT availability and performance cannot be confirmed. Conclusion: Our results suggest that striatal DAT availability may play a role in executive function as measured by the WCST.

UR - http://www.scopus.com/inward/record.url?scp=77649296742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649296742&partnerID=8YFLogxK

U2 - 10.1503/jpn.090007

DO - 10.1503/jpn.090007

M3 - Article

VL - 35

SP - 90

EP - 94

JO - Journal of Psychiatry and Neuroscience

JF - Journal of Psychiatry and Neuroscience

SN - 1180-4882

IS - 2

ER -