Correlation between fine motor activity and striatal dopamine D 2 receptor density in patients with schizophrenia and healthy controls

Yen-Kuang Yang, Nan-Tsing Chiu, Chwen Cheng Chen, Mitchell Chen, Tzung Lieh Yeh, I-Hui Lee

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Striatal dopamine D 2 receptor density is an important indicator of many neuropsychiatric disorders and also of motor activity. This study examined the relationship between a fine motor task (finger tapping test, FTT) and striatal D 2 dopamine receptor density by examining 20 healthy volunteers and 20 schizophrenic patients. Striatal D 2 receptor density was determined with single photon emission computed tomography using [ 123 I]IBZM (iodo-benzamide). The correlation between the FTT score and striatal D 2 receptor density was statistically significant not only in the patient group but also in healthy controls. The FTT scores and striatal D 2 receptor density were lower in medicated patients than that in healthy controls. Compared with the Simpson-Angus Scale scores, the FTT scores were more strongly associated with striatal D 2 receptor density. The use of neuroleptic medication seemed to influence the associations between FTT scores and striatal D 2 receptor density in the patient group. The FTT scores and striatal D 2 receptor density were age-sensitive in healthy controls. FTT may be a more sensitive tool for detecting neuroleptic-induced motor impairment in patients with schizophrenia. The sensitivity of the FTT to age and neuroleptic effects may be explained in part by a decline in dopamine D 2 density.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume123
Issue number3
DOIs
Publication statusPublished - 2003 Jul 30

Fingerprint

Corpus Striatum
Fingers
Dopamine
Schizophrenia
Motor Activity
Antipsychotic Agents
Dopamine Receptors
Single-Photon Emission-Computed Tomography
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

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Correlation between fine motor activity and striatal dopamine D 2 receptor density in patients with schizophrenia and healthy controls . / Yang, Yen-Kuang; Chiu, Nan-Tsing; Chen, Chwen Cheng; Chen, Mitchell; Yeh, Tzung Lieh; Lee, I-Hui.

In: Psychiatry Research - Neuroimaging, Vol. 123, No. 3, 30.07.2003, p. 191-197.

Research output: Contribution to journalArticle

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