Correlation between interleukin-6 levels and methadone maintenance therapy outcomes

Ru Band Lu, Tzu-Yun Wang, Sheng Yu Lee, Shiou Lan Chen, Yun Hsuan Chang, Po-See Chen, Shih Hsien Lin, Chun-Hsien Chu, San Yuan Huang, Nian Sheng Tzeng, I-Hui Lee, Kao-Ching Chen, Yen-Kuang Yang, Ping Chen, Shih Heng Chen, Jau Shyong Hong

Research output: Contribution to journalArticle

Abstract

Background: The outcome of methadone maintenance therapy (MMT) varies in each patient with opioid use disorder (OUD). Opioid abuse activates proinflammatory processes by increasing cytokine production and impairing neurotrophic factor expression, and possibly leads to a vicious cycle that hinders recovery. Therefore, we investigated whether markers of inflammation and neurotrophic expression correlate with the MMT outcomes in OUD patients. Method: We investigated OUD patients undergoing MMT and followed them up for 12 weeks. We measured plasma tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-6, IL-1β, transforming growth factor (TGF)-β1, brain-derived neurotrophic factor (BDNF), urinary morphine tests, and plasma morphine levels at baseline and on weeks 1, 4, 8, and 12 during MMT. Multiple linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the cytokine and BDNF levels and MMT outcomes. Results: We initially enrolled 104 patients, but only 78 patients completed end-of-study assessments. Plasma levels of CRP, TGF-β1, and BDNF fell during MMT. Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). However, other cytokine and BDNF levels were not consistently associated with MMT outcomes. Conclusion: Higher IL-6 levels were associated with poor MMT outcomes. Additional studies on regulating IL-6 expression to improve treatment outcomes in OUD patients might be warranted.

Original languageEnglish
Article number107516
JournalDrug and Alcohol Dependence
Volume204
DOIs
Publication statusPublished - 2019 Nov 1

Fingerprint

Methadone
Interleukin-6
Opioid Analgesics
Brain-Derived Neurotrophic Factor
Morphine
Plasmas
Therapeutics
Transforming Growth Factors
Cytokines
C-Reactive Protein
Lymphotoxin-beta
Nerve Growth Factors
Interleukin-1
Linear regression
Linear Models
Inflammation
Recovery

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Lu, Ru Band ; Wang, Tzu-Yun ; Lee, Sheng Yu ; Chen, Shiou Lan ; Chang, Yun Hsuan ; Chen, Po-See ; Lin, Shih Hsien ; Chu, Chun-Hsien ; Huang, San Yuan ; Tzeng, Nian Sheng ; Lee, I-Hui ; Chen, Kao-Ching ; Yang, Yen-Kuang ; Chen, Ping ; Chen, Shih Heng ; Hong, Jau Shyong. / Correlation between interleukin-6 levels and methadone maintenance therapy outcomes. In: Drug and Alcohol Dependence. 2019 ; Vol. 204.
@article{0517db100e4f46658e33636285eb0ea4,
title = "Correlation between interleukin-6 levels and methadone maintenance therapy outcomes",
abstract = "Background: The outcome of methadone maintenance therapy (MMT) varies in each patient with opioid use disorder (OUD). Opioid abuse activates proinflammatory processes by increasing cytokine production and impairing neurotrophic factor expression, and possibly leads to a vicious cycle that hinders recovery. Therefore, we investigated whether markers of inflammation and neurotrophic expression correlate with the MMT outcomes in OUD patients. Method: We investigated OUD patients undergoing MMT and followed them up for 12 weeks. We measured plasma tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-6, IL-1β, transforming growth factor (TGF)-β1, brain-derived neurotrophic factor (BDNF), urinary morphine tests, and plasma morphine levels at baseline and on weeks 1, 4, 8, and 12 during MMT. Multiple linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the cytokine and BDNF levels and MMT outcomes. Results: We initially enrolled 104 patients, but only 78 patients completed end-of-study assessments. Plasma levels of CRP, TGF-β1, and BDNF fell during MMT. Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). However, other cytokine and BDNF levels were not consistently associated with MMT outcomes. Conclusion: Higher IL-6 levels were associated with poor MMT outcomes. Additional studies on regulating IL-6 expression to improve treatment outcomes in OUD patients might be warranted.",
author = "Lu, {Ru Band} and Tzu-Yun Wang and Lee, {Sheng Yu} and Chen, {Shiou Lan} and Chang, {Yun Hsuan} and Po-See Chen and Lin, {Shih Hsien} and Chun-Hsien Chu and Huang, {San Yuan} and Tzeng, {Nian Sheng} and I-Hui Lee and Kao-Ching Chen and Yen-Kuang Yang and Ping Chen and Chen, {Shih Heng} and Hong, {Jau Shyong}",
year = "2019",
month = "11",
day = "1",
doi = "10.1016/j.drugalcdep.2019.06.018",
language = "English",
volume = "204",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",

}

Correlation between interleukin-6 levels and methadone maintenance therapy outcomes. / Lu, Ru Band; Wang, Tzu-Yun; Lee, Sheng Yu; Chen, Shiou Lan; Chang, Yun Hsuan; Chen, Po-See; Lin, Shih Hsien; Chu, Chun-Hsien; Huang, San Yuan; Tzeng, Nian Sheng; Lee, I-Hui; Chen, Kao-Ching; Yang, Yen-Kuang; Chen, Ping; Chen, Shih Heng; Hong, Jau Shyong.

In: Drug and Alcohol Dependence, Vol. 204, 107516, 01.11.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between interleukin-6 levels and methadone maintenance therapy outcomes

AU - Lu, Ru Band

AU - Wang, Tzu-Yun

AU - Lee, Sheng Yu

AU - Chen, Shiou Lan

AU - Chang, Yun Hsuan

AU - Chen, Po-See

AU - Lin, Shih Hsien

AU - Chu, Chun-Hsien

AU - Huang, San Yuan

AU - Tzeng, Nian Sheng

AU - Lee, I-Hui

AU - Chen, Kao-Ching

AU - Yang, Yen-Kuang

AU - Chen, Ping

AU - Chen, Shih Heng

AU - Hong, Jau Shyong

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: The outcome of methadone maintenance therapy (MMT) varies in each patient with opioid use disorder (OUD). Opioid abuse activates proinflammatory processes by increasing cytokine production and impairing neurotrophic factor expression, and possibly leads to a vicious cycle that hinders recovery. Therefore, we investigated whether markers of inflammation and neurotrophic expression correlate with the MMT outcomes in OUD patients. Method: We investigated OUD patients undergoing MMT and followed them up for 12 weeks. We measured plasma tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-6, IL-1β, transforming growth factor (TGF)-β1, brain-derived neurotrophic factor (BDNF), urinary morphine tests, and plasma morphine levels at baseline and on weeks 1, 4, 8, and 12 during MMT. Multiple linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the cytokine and BDNF levels and MMT outcomes. Results: We initially enrolled 104 patients, but only 78 patients completed end-of-study assessments. Plasma levels of CRP, TGF-β1, and BDNF fell during MMT. Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). However, other cytokine and BDNF levels were not consistently associated with MMT outcomes. Conclusion: Higher IL-6 levels were associated with poor MMT outcomes. Additional studies on regulating IL-6 expression to improve treatment outcomes in OUD patients might be warranted.

AB - Background: The outcome of methadone maintenance therapy (MMT) varies in each patient with opioid use disorder (OUD). Opioid abuse activates proinflammatory processes by increasing cytokine production and impairing neurotrophic factor expression, and possibly leads to a vicious cycle that hinders recovery. Therefore, we investigated whether markers of inflammation and neurotrophic expression correlate with the MMT outcomes in OUD patients. Method: We investigated OUD patients undergoing MMT and followed them up for 12 weeks. We measured plasma tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-6, IL-1β, transforming growth factor (TGF)-β1, brain-derived neurotrophic factor (BDNF), urinary morphine tests, and plasma morphine levels at baseline and on weeks 1, 4, 8, and 12 during MMT. Multiple linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the cytokine and BDNF levels and MMT outcomes. Results: We initially enrolled 104 patients, but only 78 patients completed end-of-study assessments. Plasma levels of CRP, TGF-β1, and BDNF fell during MMT. Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). However, other cytokine and BDNF levels were not consistently associated with MMT outcomes. Conclusion: Higher IL-6 levels were associated with poor MMT outcomes. Additional studies on regulating IL-6 expression to improve treatment outcomes in OUD patients might be warranted.

UR - http://www.scopus.com/inward/record.url?scp=85071844491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071844491&partnerID=8YFLogxK

U2 - 10.1016/j.drugalcdep.2019.06.018

DO - 10.1016/j.drugalcdep.2019.06.018

M3 - Article

AN - SCOPUS:85071844491

VL - 204

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

M1 - 107516

ER -