Correlation between plasma cortisol and CSF catecholamines in endogenous depressed dexamethasone nonsuppressors

Ru Band Lu, Swui Ling Ho, Beng T. Ho, Shou Yorn Leu, Lee Ren Shian, Wei Lian Chen

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Nineteen endogenous depressive in-patients (13 with major depression and 6 with bipolar disorder-depressed) and 10 other patients with dysthymic disorder serving as the control group were given the dexamethasone suppression test (DST, 1 mg/subject). The results showed that the DST sensitivity in endogenous depressives was 73.7% and the specificity was 90%. After the patients were treated daily for 6 weeks with 150-200 mg imipramine, 88.9% of those endogenous depressive patients who previously had a positive DST response exhibited a negative response. Moreover, a significantly negative correlation was found between the CSF norepinephrine level and the pre-dexamethasone 4 p.m. plasma cortisol level in those endogeous depressed patients who had a positive DST response. Pre-treatment data also showed that the 4 p.m. plasma cortisol had a significant negative correlation with CSF dopamine. These findings suggest that endogenous depression with positive DST could be related not only to a lower norepinephrine level, but also to a lower dopamine level.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalJournal of Affective Disorders
Volume10
Issue number3
DOIs
Publication statusPublished - 1986

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

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