Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

Hsien Jen Cheng; Yueh Hsia Luo; Shu Wen Wan; Chiou Feng Lin; Shan Tair Wang; Nguyen Thanh Hung; Ching Chuan Liu; Tzong Shiann Ho; Hsiao Sheng Liu; Trai Ming Yeh; Yee Shin Lin

doi:10.4269/ajtmh.14-0162

Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

Hsien Jen Cheng, Yueh Hsia Luo, Shu Wen Wan, Chiou Feng Lin, Shan Tair Wang, Nguyen Thanh Hung, Ching Chuan Liu, Tzong Shiann Ho, Hsiao Sheng Liu, Trai Ming Yeh, Yee Shin Lin

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Abstract

We have previously shown that anti-dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti-protein disulfide isomerase (PDI) and anti-heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti-endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311-330 (P311-330) had been predicted. We further found that there were higher IgM and IgG levels against P311-330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P311-330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311-330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection-induced autoimmunity.

Original language	English
Pages (from-to)	989-995
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	92
Issue number	5
DOIs	https://doi.org/10.4269/ajtmh.14-0162
Publication status	Published - 2015 May 1

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology
Parasitology

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Cheng, H. J., Luo, Y. H., Wan, S. W., Lin, C. F., Wang, S. T., Hung, N. T., Liu, C. C., Ho, T. S., Liu, H. S., Yeh, T. M., & Lin, Y. S. (2015). Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients. American Journal of Tropical Medicine and Hygiene, 92(5), 989-995. https://doi.org/10.4269/ajtmh.14-0162

@article{573f52b76d894a5d849585e3b55d3687,

title = "Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients",

abstract = "We have previously shown that anti-dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti-protein disulfide isomerase (PDI) and anti-heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti-endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311-330 (P311-330) had been predicted. We further found that there were higher IgM and IgG levels against P311-330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P311-330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311-330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection-induced autoimmunity.",

author = "Cheng, {Hsien Jen} and Luo, {Yueh Hsia} and Wan, {Shu Wen} and Lin, {Chiou Feng} and Wang, {Shan Tair} and Hung, {Nguyen Thanh} and Liu, {Ching Chuan} and Ho, {Tzong Shiann} and Liu, {Hsiao Sheng} and Yeh, {Trai Ming} and Lin, {Yee Shin}",

note = "Publisher Copyright: Copyright {\textcopyright} 2015 by The American Society of Tropical Medicine and Hygiene.",

year = "2015",

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doi = "10.4269/ajtmh.14-0162",

language = "English",

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Cheng, HJ, Luo, YH, Wan, SW, Lin, CF, Wang, ST, Hung, NT, Liu, CC, Ho, TS, Liu, HS, Yeh, TM & Lin, YS 2015, 'Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients', American Journal of Tropical Medicine and Hygiene, vol. 92, no. 5, pp. 989-995. https://doi.org/10.4269/ajtmh.14-0162

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T1 - Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

AU - Cheng, Hsien Jen

AU - Luo, Yueh Hsia

AU - Wan, Shu Wen

AU - Lin, Chiou Feng

AU - Wang, Shan Tair

AU - Hung, Nguyen Thanh

AU - Liu, Ching Chuan

AU - Ho, Tzong Shiann

AU - Liu, Hsiao Sheng

AU - Yeh, Trai Ming

AU - Lin, Yee Shin

PY - 2015/5/1

Y1 - 2015/5/1

N2 - We have previously shown that anti-dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti-protein disulfide isomerase (PDI) and anti-heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti-endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311-330 (P311-330) had been predicted. We further found that there were higher IgM and IgG levels against P311-330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P311-330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311-330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection-induced autoimmunity.

AB - We have previously shown that anti-dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti-protein disulfide isomerase (PDI) and anti-heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti-endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311-330 (P311-330) had been predicted. We further found that there were higher IgM and IgG levels against P311-330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P311-330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311-330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection-induced autoimmunity.

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Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

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