Correlation between striatal dopamine D2 receptor density and neuroticism in community volunteers

I. Hui Lee; Chwen Cheng Cheng; Yen Kuang Yang; Tzung Lieh Yeh; Po See Chen; Nan Tsing Chiu

doi:10.1016/j.pscychresns.2005.02.002

Correlation between striatal dopamine D₂ receptor density and neuroticism in community volunteers

I. Hui Lee
, Chwen Cheng Cheng
, Yen Kuang Yang
, Tzung Lieh Yeh
, Po See Chen
, Nan Tsing Chiu

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The central dopaminergic system, as well as the central serotonergic system, has been reported to be correlated with higher neuroticism. The present study examined the relationship between striatal dopamine D₂ receptor density and neuroticism. Neuroticism was assessed with the Maudsley Personality Inventory, and psychiatric morbidity was evaluated with both the Mini International Neuropsychiatric Interview and the Hamilton Depression Rating Scale (HAM-D). Single photon emission computed tomography with [ ¹²³I]iodo-benzamide was used to measure striatal dopamine D ₂ receptor density. HAM-D scores and psychiatric morbidity in high-neuroticism individuals were higher than in low-neuroticism individuals. Moreover, striatal dopamine D₂ receptor densities were significantly correlated with the neuroticism score of the 41 subjects. The central dopaminergic system may play an important role in the neurobiological characteristics of neuroticism.

Original language	English
Pages (from-to)	259-264
Number of pages	6
Journal	Psychiatry Research - Neuroimaging
Volume	138
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2005.02.002
Publication status	Published - 2005 Apr 30

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

Access to Document

10.1016/j.pscychresns.2005.02.002

Cite this

@article{877ecb2453d5441998def82b29f9e6e6,

title = "Correlation between striatal dopamine D2 receptor density and neuroticism in community volunteers",

abstract = "The central dopaminergic system, as well as the central serotonergic system, has been reported to be correlated with higher neuroticism. The present study examined the relationship between striatal dopamine D2 receptor density and neuroticism. Neuroticism was assessed with the Maudsley Personality Inventory, and psychiatric morbidity was evaluated with both the Mini International Neuropsychiatric Interview and the Hamilton Depression Rating Scale (HAM-D). Single photon emission computed tomography with [ 123I]iodo-benzamide was used to measure striatal dopamine D 2 receptor density. HAM-D scores and psychiatric morbidity in high-neuroticism individuals were higher than in low-neuroticism individuals. Moreover, striatal dopamine D2 receptor densities were significantly correlated with the neuroticism score of the 41 subjects. The central dopaminergic system may play an important role in the neurobiological characteristics of neuroticism.",

author = "Lee, \{I. Hui\} and Cheng, \{Chwen Cheng\} and Yang, \{Yen Kuang\} and Yeh, \{Tzung Lieh\} and Chen, \{Po See\} and Chiu, \{Nan Tsing\}",

note = "Funding Information: The work was supported by the Atomic Energy Council, Taiwan (N3I102; NSC90-NU-7-006-004; NSC91-NU-7-006-002 to Y.K. Yang, and NSC89-NU-7-006-002 to C.C. Chen). The authors thank Mitchell Chen, Chih Ming Tsai, Ching Lin Chu, Shu Chuan Lin, and Linda J. Chang for their editorial, administrative, and statistical assistance in the preparation of this article.",

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doi = "10.1016/j.pscychresns.2005.02.002",

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AU - Lee, I. Hui

AU - Cheng, Chwen Cheng

AU - Yang, Yen Kuang

AU - Yeh, Tzung Lieh

AU - Chen, Po See

AU - Chiu, Nan Tsing

N1 - Funding Information: The work was supported by the Atomic Energy Council, Taiwan (N3I102; NSC90-NU-7-006-004; NSC91-NU-7-006-002 to Y.K. Yang, and NSC89-NU-7-006-002 to C.C. Chen). The authors thank Mitchell Chen, Chih Ming Tsai, Ching Lin Chu, Shu Chuan Lin, and Linda J. Chang for their editorial, administrative, and statistical assistance in the preparation of this article.

PY - 2005/4/30

Y1 - 2005/4/30

N2 - The central dopaminergic system, as well as the central serotonergic system, has been reported to be correlated with higher neuroticism. The present study examined the relationship between striatal dopamine D2 receptor density and neuroticism. Neuroticism was assessed with the Maudsley Personality Inventory, and psychiatric morbidity was evaluated with both the Mini International Neuropsychiatric Interview and the Hamilton Depression Rating Scale (HAM-D). Single photon emission computed tomography with [ 123I]iodo-benzamide was used to measure striatal dopamine D 2 receptor density. HAM-D scores and psychiatric morbidity in high-neuroticism individuals were higher than in low-neuroticism individuals. Moreover, striatal dopamine D2 receptor densities were significantly correlated with the neuroticism score of the 41 subjects. The central dopaminergic system may play an important role in the neurobiological characteristics of neuroticism.

AB - The central dopaminergic system, as well as the central serotonergic system, has been reported to be correlated with higher neuroticism. The present study examined the relationship between striatal dopamine D2 receptor density and neuroticism. Neuroticism was assessed with the Maudsley Personality Inventory, and psychiatric morbidity was evaluated with both the Mini International Neuropsychiatric Interview and the Hamilton Depression Rating Scale (HAM-D). Single photon emission computed tomography with [ 123I]iodo-benzamide was used to measure striatal dopamine D 2 receptor density. HAM-D scores and psychiatric morbidity in high-neuroticism individuals were higher than in low-neuroticism individuals. Moreover, striatal dopamine D2 receptor densities were significantly correlated with the neuroticism score of the 41 subjects. The central dopaminergic system may play an important role in the neurobiological characteristics of neuroticism.

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