Correlation of IFN-inducible protein 10 levels in Sera with disease severity and clinical outcome of the dengue patients

Ying Ray Lee, Nguyen Thanh Hung, Ching Chuan Liu, Kao Jean Huang, Huan Yao Lei, Yee Shin Lin, Jen Reng Wang, Trai Ming Yeh, Shun Hua Chen, Hsiao Sheng Liu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.

Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalAmerican Journal of Infectious Diseases
Volume4
Issue number1
DOIs
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

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