Correlation of IFN-inducible protein 10 levels in Sera with disease severity and clinical outcome of the dengue patients

Ying Ray Lee; Nguyen Thanh Hung; Ching Chuan Liu; Kao Jean Huang; Huan Yao Lei; Yee Shin Lin; Jen Reng Wang; Trai Ming Yeh; Shun Hua Chen; Hsiao Sheng Liu

doi:10.3844/ajidsp.2008.18.21

Correlation of IFN-inducible protein 10 levels in Sera with disease severity and clinical outcome of the dengue patients

Ying Ray Lee, Nguyen Thanh Hung, Ching Chuan Liu, Kao Jean Huang, Huan Yao Lei, Yee Shin Lin, Jen Reng Wang, Trai Ming Yeh, Shun Hua Chen, Hsiao Sheng Liu

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.

Original language	English
Pages (from-to)	18-21
Number of pages	4
Journal	American Journal of Infectious Diseases
Volume	4
Issue number	1
DOIs	https://doi.org/10.3844/ajidsp.2008.18.21
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3844/ajidsp.2008.18.21

Cite this

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title = "Correlation of IFN-inducible protein 10 levels in Sera with disease severity and clinical outcome of the dengue patients",

abstract = "Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.",

author = "Lee, {Ying Ray} and Hung, {Nguyen Thanh} and Liu, {Ching Chuan} and Huang, {Kao Jean} and Lei, {Huan Yao} and Lin, {Yee Shin} and Wang, {Jen Reng} and Yeh, {Trai Ming} and Chen, {Shun Hua} and Liu, {Hsiao Sheng}",

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T1 - Correlation of IFN-inducible protein 10 levels in Sera with disease severity and clinical outcome of the dengue patients

AU - Lee, Ying Ray

AU - Hung, Nguyen Thanh

AU - Liu, Ching Chuan

AU - Huang, Kao Jean

AU - Lei, Huan Yao

AU - Lin, Yee Shin

AU - Wang, Jen Reng

AU - Yeh, Trai Ming

AU - Chen, Shun Hua

AU - Liu, Hsiao Sheng

PY - 2008

Y1 - 2008

N2 - Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.

AB - Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.

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Correlation of IFN-inducible protein 10 levels in Sera with disease severity and clinical outcome of the dengue patients

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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