TY - JOUR
T1 - Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients
AU - Chen, Lien Cheng
AU - Lei, Huan Yao
AU - Liu, Ching Chuan
AU - Shiesh, Shu Chu
AU - Chen, Shun Hua
AU - Liu, Hsiao Sheng
AU - Lin, Yee Shin
AU - Wang, Shan Tair
AU - Shyu, Huey Wen
AU - Yeh, Trai Ming
PY - 2006/1
Y1 - 2006/1
N2 - Dengue virus infection can cause mild dengue fever (DF) or severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Cytokines are believed to be involved in the pathogenesis of dengue infection. However, the role of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) in dengue infection is unclear. In this study, serum levels of MIF in adult dengue patients with different disease severity and clinical outcome were determined and compared with the levels of other cytokines, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-10, and interferon gamma (IFN-γ), in the same patients. Serum levels of MIF, IL-6, and IL-10, but not IFN-γ or TNF-α, were higher in all DHF patients who died than in DHF survivors and DF patients. We conclude that in addition to IL-6 and IL-10, elevated levels of serum MIF are a potential predictor of disease severity and clinical outcome in dengue patients.
AB - Dengue virus infection can cause mild dengue fever (DF) or severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Cytokines are believed to be involved in the pathogenesis of dengue infection. However, the role of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) in dengue infection is unclear. In this study, serum levels of MIF in adult dengue patients with different disease severity and clinical outcome were determined and compared with the levels of other cytokines, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-10, and interferon gamma (IFN-γ), in the same patients. Serum levels of MIF, IL-6, and IL-10, but not IFN-γ or TNF-α, were higher in all DHF patients who died than in DHF survivors and DF patients. We conclude that in addition to IL-6 and IL-10, elevated levels of serum MIF are a potential predictor of disease severity and clinical outcome in dengue patients.
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U2 - 10.4269/ajtmh.2006.74.142
DO - 10.4269/ajtmh.2006.74.142
M3 - Article
C2 - 16407359
AN - SCOPUS:33646002654
SN - 0002-9637
VL - 74
SP - 142
EP - 147
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -