Correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice

Chaitanya Kurhade; Sarah Schreier; Yi Ping Lee; Loreen Zegenhagen; Marika Hjertqvist; Gerhard Dobler; Andrea Kröger; Anna K. Överby

doi:10.3201/eid2409.171825

Correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice

Chaitanya Kurhade, Sarah Schreier, Yi Ping Lee, Loreen Zegenhagen, Marika Hjertqvist, Gerhard Dobler, Andrea Kröger, Anna K. Överby

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.

Original language	English
Pages (from-to)	1709-1712
Number of pages	4
Journal	Emerging infectious diseases
Volume	24
Issue number	9
DOIs	https://doi.org/10.3201/eid2409.171825
Publication status	Published - 2018 Sept

All Science Journal Classification (ASJC) codes

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.3201/eid2409.171825

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abstract = "We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.",

author = "Chaitanya Kurhade and Sarah Schreier and Lee, {Yi Ping} and Loreen Zegenhagen and Marika Hjertqvist and Gerhard Dobler and Andrea Kr{\"o}ger and {\"O}verby, {Anna K.}",

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AU - Kurhade, Chaitanya

AU - Schreier, Sarah

AU - Lee, Yi Ping

AU - Zegenhagen, Loreen

AU - Hjertqvist, Marika

AU - Dobler, Gerhard

AU - Kröger, Andrea

AU - Överby, Anna K.

PY - 2018/9

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AB - We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.

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Correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice

Abstract

All Science Journal Classification (ASJC) codes

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