Cortisol response to ACTH infusion in depressed patients: comparison with age-, sex-, and weight-matched normal subjects

Victor S. Fang, H. K. Jlang, Ru Band Lu, Robert P. Rose, Daniel J. Luchins

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Adrenal responsiveness to Cosyntropin (synthetic ACTH1-24) was investigated in five patients with major depression and five individually matched normal subjects. Three hours following suppression of endogenous ACTH secretion with dexamethasone (1 mg orally), the adrenal response to a 10-min infusion of Cosyntropin (0.05 μg/kg body weight) was monitored for 2 1 2 hr by plasma cortisol measured at 15-min intervals. The depressed patients had significantly higher baseline plasma cortisol, but not higher baseline ACTH, than the controls. During the 3-hr post-dexamethasone (and prior to Cosyntropin infusion), the depressed patients maintained significantly higher cortisol secretion, but not higher ACTH secretion, than the controls. After Cosyntropin infusion, there were no differences in ACTH and cortisol increases between the two groups. These findings stand in contrast to previous reports of enhanced adrenal responsiveness to the administration of much larger amounts of Cosyntropin in major depression.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalPsychoneuroendocrinology
Volume13
Issue number6
DOIs
Publication statusPublished - 1988

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

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