COVID-19-associated candidiasis and the emerging concern of Candida auris infections

Chin Shiang Tsai, Susan Shin Jung Lee, Wan Chen Chen, Chien Hao Tseng, Nan Yao Lee, Po Lin Chen, Ming Chi Li, Ling Shan Syue, Ching Lung Lo, Wen Chien Ko, Yuan Pin Hung

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


The incidence of COVID-19-associated candidiasis (CAC) is increasing, resulting in a grave outcome among hospitalized patients with COVID-19. The most alarming condition is the increasing incidence of multi-drug resistant Candida auris infections among patients with COVID-19 worldwide. The therapeutic strategy towards CAC caused by common Candida species, such as Candida albicans, Candida tropicalis, and Candida glabrata, is similar to the pre-pandemic era. For non-critically ill patients or those with a low risk of azole resistance, fluconazole remains the drug of choice for candidemia. For critically ill patients, those with a history of recent azole exposure or with a high risk of fluconazole resistance, echinocandins are recommended as the first-line therapy. Several novel therapeutic agents alone or in combination with traditional antifungal agents for candidiasis are potential options in the future. However, for multidrug-resistant C. auris infection, only echinocandins are effective. Infection prevention and control policies, including strict isolation of the patients carrying C. auris and regular screening of non-affected patients, are suggested to prevent the spread of C. auris among patients with COVID-19. Whole-genome sequencing may be used to understand the epidemiology of healthcare-associated candidiasis and to better control and prevent these infections.

Original languageEnglish
Pages (from-to)672-679
Number of pages8
JournalJournal of Microbiology, Immunology and Infection
Issue number4
Publication statusPublished - 2023 Aug

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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