Cross-linked, self-fluorescent gold nanoparticle/polypeptide nanocapsules comprising dityrosine for protein encapsulation and label-free imaging

Yi Fong Huang, Sheing Chung Lu, Yun Chiao Huang, Jeng Shiung Jan

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Cross-linked, self-fluorescent Au nanoparticle/polypeptide nanocapsules comprising dityrosine are prepared by the self-assembly of the random copolypeptides comprising L-lysine and L-tyrosine upon subsequent cross-linking of tyrosine residues by chloroaurate reduction. These nanocapsules are demonstrated be useful as encapsulants for protein encapsulation and as optical probes for label-free cell imaging. The reduction process is so mild that the protein can still retain its function.

Original languageEnglish
Pages (from-to)1939-1944
Number of pages6
JournalSmall
Volume10
Issue number10
DOIs
Publication statusPublished - 2014 May 28

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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