This research focuses on analyzing the two prime science and technology (S&T) strategy approaches for industrial evolution based on the concept of S&T gap, namely, the optimist and pragmatist approaches. Particularly, the cases of global IC, pharmaceutical, and computer industries, are used to make cross-national and cross-industrial comparison of these two approaches. The optimist approach is developed based on the product life cycle theory which envisions technology transcending everyday limitations. With this perspective, market demand is the most critical factor in selecting the S&T strategy approaches. The pragmatist approach is formed based on the new trade theory which recognizes the power of science and technology but seeks to fit it into structures that already exist, and government must manage resources pouring into science and technology. Case studies of global IC, pharmaceutical, and computer industries during the 2nd half of the 20th century are used as research targets to reflect policy impacts on the technological evolution. The results of this study reveal that, strategy approaches have to be adapted and turned to the specific stage, technology level, and market segment that have been selected for intervention. This result of comparison also offers the criteria of strategy approach selection for developing different industry based on distinct national base.