CSF neurochemical study of tardive dyskinesia

Lu Ru-Band Lu, Ko Huei-Chen Ko, Lin Wen-Long Lin, Lin Yu-Tsai Lin, Ho Swui-Ling Ho

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10 Citations (Scopus)


Twenty-three inpatients who met DSM-III criteria for schizophrenia were selected for cerebrospinal fluid (CSF) neurochemical study of tardive dyskinesia (TD). Ten inpatients had tardive dyskinesia, and the remaining 13 patients without TD served as controls. There were no intergroup differences in sex, age, duration of neuroleptic treatment, or in total amount of neuroleptics received between the TD and the control groups. Cerebrospinal fluid was collected by lumbar puncture, and concentrations of homovanillic acid (HVA), MHPG, 5-hydroxyindoleacetic acid (5-HIAA), and acetylcholinesterase (AChE) activity were measured. The concentrations of MHPG (TD 11.56 ± 3.48 ng/ml versus control 14.20 ± 3.86 ng/ml), 5-HIAA (45.27 ± 9.77 ng/ml versus 40.34 ± 13.77 ng/ml), and HVA (38.26 ± 75.31 ng/ml versus 31.40 ± 7.83 ng/ml), and the activity of AChE (TD 7.95 ± 5.21 mmol/g· hr versus control 12.89 ± 8.04 mmol/g · hr) showed no significant differences between the two groups, but the ratios of HVA/AChE (t = 2.21, p = 0.05), 5-HIAA/AChE (t = 2.62, p = 0.02), MHPG/HVA (t = -2.16,p = 0.04), and MHPG/5-HIAA (t = -2.48, p = 0.02) were statistically different. The results indicated that TD might involve an imbalance of dopamine-acetylcholine, noradrenalin-dopamine, noradrenalin-serotonin, and serotonin-acetylcholine.

Original languageEnglish
Pages (from-to)717-724
Number of pages8
JournalBiological Psychiatry
Issue number6
Publication statusPublished - 1989 Mar 15

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry


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