TY - JOUR
T1 - CSF neurochemical study of tardive dyskinesia
AU - Ru-Band Lu, Lu
AU - Huei-Chen Ko, Ko
AU - Wen-Long Lin, Lin
AU - Yu-Tsai Lin, Lin
AU - Swui-Ling Ho, Ho
N1 - Funding Information:
From the Departmento f Psychiatry, Tri-Service CienexalH ospitaI, National Defense Medical Center I$.-B.L., H.-C.K., Y.- T.L., S.-L.H.) and the 818 Army Hospital fW.-L.L.), Taipei, Taiwan, Republic of China. Supported in pzut by tbe National Science Council, Republic of China, Grant NSC74-0412-BOlG54. Address mpriut requests to Dr. Ru-Band Lu, Departmento f Psychiatry, T&Service General Hospital, 622 Tin&how Road. Taipei, Taiwan, Republic of Cbii. Received April 8, 1988; revised June 13, 1988.
PY - 1989/3/15
Y1 - 1989/3/15
N2 - Twenty-three inpatients who met DSM-III criteria for schizophrenia were selected for cerebrospinal fluid (CSF) neurochemical study of tardive dyskinesia (TD). Ten inpatients had tardive dyskinesia, and the remaining 13 patients without TD served as controls. There were no intergroup differences in sex, age, duration of neuroleptic treatment, or in total amount of neuroleptics received between the TD and the control groups. Cerebrospinal fluid was collected by lumbar puncture, and concentrations of homovanillic acid (HVA), MHPG, 5-hydroxyindoleacetic acid (5-HIAA), and acetylcholinesterase (AChE) activity were measured. The concentrations of MHPG (TD 11.56 ± 3.48 ng/ml versus control 14.20 ± 3.86 ng/ml), 5-HIAA (45.27 ± 9.77 ng/ml versus 40.34 ± 13.77 ng/ml), and HVA (38.26 ± 75.31 ng/ml versus 31.40 ± 7.83 ng/ml), and the activity of AChE (TD 7.95 ± 5.21 mmol/g· hr versus control 12.89 ± 8.04 mmol/g · hr) showed no significant differences between the two groups, but the ratios of HVA/AChE (t = 2.21, p = 0.05), 5-HIAA/AChE (t = 2.62, p = 0.02), MHPG/HVA (t = -2.16,p = 0.04), and MHPG/5-HIAA (t = -2.48, p = 0.02) were statistically different. The results indicated that TD might involve an imbalance of dopamine-acetylcholine, noradrenalin-dopamine, noradrenalin-serotonin, and serotonin-acetylcholine.
AB - Twenty-three inpatients who met DSM-III criteria for schizophrenia were selected for cerebrospinal fluid (CSF) neurochemical study of tardive dyskinesia (TD). Ten inpatients had tardive dyskinesia, and the remaining 13 patients without TD served as controls. There were no intergroup differences in sex, age, duration of neuroleptic treatment, or in total amount of neuroleptics received between the TD and the control groups. Cerebrospinal fluid was collected by lumbar puncture, and concentrations of homovanillic acid (HVA), MHPG, 5-hydroxyindoleacetic acid (5-HIAA), and acetylcholinesterase (AChE) activity were measured. The concentrations of MHPG (TD 11.56 ± 3.48 ng/ml versus control 14.20 ± 3.86 ng/ml), 5-HIAA (45.27 ± 9.77 ng/ml versus 40.34 ± 13.77 ng/ml), and HVA (38.26 ± 75.31 ng/ml versus 31.40 ± 7.83 ng/ml), and the activity of AChE (TD 7.95 ± 5.21 mmol/g· hr versus control 12.89 ± 8.04 mmol/g · hr) showed no significant differences between the two groups, but the ratios of HVA/AChE (t = 2.21, p = 0.05), 5-HIAA/AChE (t = 2.62, p = 0.02), MHPG/HVA (t = -2.16,p = 0.04), and MHPG/5-HIAA (t = -2.48, p = 0.02) were statistically different. The results indicated that TD might involve an imbalance of dopamine-acetylcholine, noradrenalin-dopamine, noradrenalin-serotonin, and serotonin-acetylcholine.
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U2 - 10.1016/0006-3223(89)90243-6
DO - 10.1016/0006-3223(89)90243-6
M3 - Article
C2 - 2466490
AN - SCOPUS:0024595150
VL - 25
SP - 717
EP - 724
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 6
ER -