TY - JOUR
T1 - Curcumin-c3 complexed with α-, β-cyclodextrin exhibits antibacterial and antioxidant properties suitable for cancer treatments
AU - Kumar, Ramya
AU - Wang, Shao Pin
AU - Huang, Fu Yung
N1 - Funding Information:
The financial support for this study (Grant No. R108-2230) was received from National Cheng Kung University, Tainan, Taiwan.
Publisher Copyright:
© 2019 Bentham Science Publishers.
PY - 2019
Y1 - 2019
N2 - Background: The curcumin-C3 (cur-C3) complex obtained from Curcuma longa rhizome is a combination of three curcuminoids, namely, curcumin, dimethoxycurcumin, and bisdemethoxycurcumin. Cur and curcuminoids have been extensively researched for their wide range of therapeutic properties against inflammatory diseases, diabetes, and cancer. Objective: In spite of their extensive medicinal properties, cur and curcuminoids have poor solubility and bioavailability due to their hydrophobicity. This limitation can be overcome by complexing cur-C3 with natural cyclic oligo-saccharides, such as Cyclodextrin (CD). Methods: In this study, cur-C3 and CD (α, β) inclusion complexes (ICs) were prepared with different molar ratios and characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy, X-ray diffraction, and transmission electron microscopy. Results: The cur-C3 cyclodextrin ICs showed an increased entrapment efficiency of 97.8% and improved antioxidant activity compared to cur and can be used as an antioxidant to reduce cancer-related oxidative stress. Additionally, α-CD ICs of curcumin-C3 caused an increase in growth inhibition of Staphylococcus aureus. Conclusion: Our findings suggest that both α-and β-CDs are suitable carriers for cur-C3 and can be used as an effective treatment for cancer-associated oxidative stress and as a preventive treatment for nosocomial infections and pneumonia.
AB - Background: The curcumin-C3 (cur-C3) complex obtained from Curcuma longa rhizome is a combination of three curcuminoids, namely, curcumin, dimethoxycurcumin, and bisdemethoxycurcumin. Cur and curcuminoids have been extensively researched for their wide range of therapeutic properties against inflammatory diseases, diabetes, and cancer. Objective: In spite of their extensive medicinal properties, cur and curcuminoids have poor solubility and bioavailability due to their hydrophobicity. This limitation can be overcome by complexing cur-C3 with natural cyclic oligo-saccharides, such as Cyclodextrin (CD). Methods: In this study, cur-C3 and CD (α, β) inclusion complexes (ICs) were prepared with different molar ratios and characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy, X-ray diffraction, and transmission electron microscopy. Results: The cur-C3 cyclodextrin ICs showed an increased entrapment efficiency of 97.8% and improved antioxidant activity compared to cur and can be used as an antioxidant to reduce cancer-related oxidative stress. Additionally, α-CD ICs of curcumin-C3 caused an increase in growth inhibition of Staphylococcus aureus. Conclusion: Our findings suggest that both α-and β-CDs are suitable carriers for cur-C3 and can be used as an effective treatment for cancer-associated oxidative stress and as a preventive treatment for nosocomial infections and pneumonia.
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U2 - 10.2174/1389200220666191001104834
DO - 10.2174/1389200220666191001104834
M3 - Article
C2 - 31573881
AN - SCOPUS:85078485648
SN - 1389-2002
VL - 20
SP - 988
EP - 1001
JO - Current Drug Metabolism
JF - Current Drug Metabolism
IS - 12
ER -