TY - JOUR
T1 - Current diagnostic tools for coronaviruses–From laboratory diagnosis to POC diagnosis for COVID-19
AU - Wang, Yung Chih
AU - Lee, Yi Tzu
AU - Yang, Ting
AU - Sun, Jun Ren
AU - Shen, Ching Fen
AU - Cheng, Chao Min
N1 - Funding Information:
This work was supported by grants from the Taipei Veterans General Hospital [V108C‐012 V109C‐012 VTA108‐T‐2‐3 VTA109‐T‐3‐2], Tri‐Service General Hospital [TSGH‐E‐109237], and National Tsing Hua University [COVID‐19 project; 109Q2806E1]. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point-of-care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource-limited areas, and even in clinical settings. In this article, we summarize the current state of COVID-19 diagnostic methods and make a case for an all-in-one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID-19 infection. We believe this article will provide insights into the current state of diagnostics for COVID-19, and promote additional research and tool development that could be exceptionally impactful.
AB - The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point-of-care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource-limited areas, and even in clinical settings. In this article, we summarize the current state of COVID-19 diagnostic methods and make a case for an all-in-one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID-19 infection. We believe this article will provide insights into the current state of diagnostics for COVID-19, and promote additional research and tool development that could be exceptionally impactful.
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U2 - 10.1002/btm2.10177
DO - 10.1002/btm2.10177
M3 - Review article
AN - SCOPUS:85089388787
SN - 2380-6761
VL - 5
JO - Bioengineering and Translational Medicine
JF - Bioengineering and Translational Medicine
IS - 3
M1 - e10177
ER -