Current diagnostic tools for coronaviruses–From laboratory diagnosis to POC diagnosis for COVID-19

Yung Chih Wang, Yi Tzu Lee, Ting Yang, Jun Ren Sun, Ching Fen Shen, Chao Min Cheng

Research output: Contribution to journalReview article

Abstract

The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point-of-care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource-limited areas, and even in clinical settings. In this article, we summarize the current state of POC tools and propose an all-in-one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID-19 infection. We believe this article will provide insight into the current state of POC diagnostics for COVID-19, and promote additional research and tool development that could be exceptionally impactful.

Original languageEnglish
JournalBioengineering and Translational Medicine
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biotechnology
  • Medicine(all)
  • Pharmaceutical Science

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