Current progress in antivascular tumor therapy

Yi Ju Ho, Tzu Chia Wang, Ching Hsiang Fan, Chih Kuang Yeh

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

The tumor vasculature transports oxygen, nutrients and drugs for crucial roles in tumor therapy. Antivascular therapy directly targets existing tumor vessels to reduce blood perfusion and then inhibit tumor growth. Vascular disrupting agents and ultrasound-stimulated microbubble destruction use chemical toxicity and physical effect, respectively, to damage vascular endothelial cells for antivascular therapy. Moreover, antivascular therapy can break vessel wall barriers and change the tumor microenvironment to compensate for the limitations of conventional chemotherapy or radiotherapy. This review presents current progress and an overview of antivascular therapy, which can inform the development and application in cancer research. This review presents current progress and an overview of antivascular therapy to inform its development and application in cancer research.

Original languageEnglish
Pages (from-to)1503-1515
Number of pages13
JournalDrug Discovery Today
Volume22
Issue number10
DOIs
Publication statusPublished - 2017 Oct

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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